A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008

Valienamine is the key functional component of many natural glycosidase inhibitors, including the crop protectant validamycin A and the clinical antidiabetic agent acarbose. Due to its important biomedical activity, it is also the prominent lead compound for the exploration of therapeutic agents, su...

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Veröffentlicht in:	ACS synthetic biology 2020-02, Vol.9 (2), p.294-303
Hauptverfasser:	Cui, Li, Wei, Xiaodong, Wang, Xinran, Bai, Linquan, Lin, Shuangjun, Feng, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Catalytic Domain Cyclohexenes - chemistry Cyclohexenes - metabolism Escherichia coli - enzymology Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Hexosamines - biosynthesis Hexosamines - chemistry Hexosamines - metabolism Inositol - analogs & derivatives Inositol - chemistry Inositol - metabolism Kinetics Molecular Docking Simulation Mutagenesis, Site-Directed Streptomyces - chemistry Streptomyces - metabolism Transaminases - chemistry Transaminases - genetics Transaminases - metabolism
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