Mechanoredox Enabled the Difunctionalization of Unactivated Alkenes via Distal Functional Group Migration

Mechanoredox Enabled the Difunctionalization of Unactivated Alkenes via Distal Functional Group Migration

A novel mechanochemical method was proposed to achieve a radical-mediated carbotrifluoromethylation of unactivated alkenes by merging piezoelectric materials BaTiO3 and ball milling, which has significant advantages, such as ease of handling, recyclable catalysts, air compatibility, and less solvent...

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Veröffentlicht in:ACS sustainable chemistry & engineering 2023-12, Vol.11 (50), p.17816-17825
Hauptverfasser: Niu, Sheng-Li, Yuan, Wen, Gong, Xue, Bao, Bo, Wu, Zhi-Wen, Xu, Bo, Zeng, Rong, Yang, Qing-Wu, Ouyang, Qin
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container_issue 50
container_start_page 17816
container_title ACS sustainable chemistry & engineering
container_volume 11
creator Niu, Sheng-Li
Yuan, Wen
Gong, Xue
Bao, Bo
Wu, Zhi-Wen
Xu, Bo
Zeng, Rong
Yang, Qing-Wu
Ouyang, Qin
description A novel mechanochemical method was proposed to achieve a radical-mediated carbotrifluoromethylation of unactivated alkenes by merging piezoelectric materials BaTiO3 and ball milling, which has significant advantages, such as ease of handling, recyclable catalysts, air compatibility, and less solvent consumption. In addition to its wide substrate applicability, this method has also been proven to be a robust and green approach through an up-scaled experiment, catalyst recycling experiment, and green chemistry metrics analysis. The efficient and sustainable mechanoredox strategy is first used for a multiple cascade radical reaction and provides green and rapid access to the difunctionalized fluorine-containing ketone scaffolds.
doi_str_mv 10.1021/acssuschemeng.3c06118
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title Mechanoredox Enabled the Difunctionalization of Unactivated Alkenes via Distal Functional Group Migration
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