Discovery of the First Selective M 4 Muscarinic Acetylcholine Receptor Antagonists with in Vivo Antiparkinsonian and Antidystonic Efficacy

Nonselective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson's disease and dystonia. Despite their efficacy in these and other central nervous system disorde...

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Veröffentlicht in:	ACS pharmacology & translational science 2021-08, Vol.4 (4), p.1306-1321
Hauptverfasser:	Moehle, Mark S, Bender, Aaron M, Dickerson, Jonathan W, Foster, Daniel J, Qi, Aidong, Cho, Hyekyung P, Donsante, Yuping, Peng, Weimin, Bryant, Zoey, Stillwell, Kaylee J, Bridges, Thomas M, Chang, Sichen, Watson, Katherine J, O'Neill, Jordan C, Engers, Julie L, Peng, Li, Rodriguez, Alice L, Niswender, Colleen M, Lindsley, Craig W, Hess, Ellen J, Conn, P Jeffrey, Rook, Jerri M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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