Ultrasound-Switchable Nanozyme Augments Sonodynamic Therapy against Multidrug-Resistant Bacterial Infection

Ultrasound (US)-driven sonodynamic therapy (SDT) has demonstrated wide application prospects in the eradication of deep-seated bacterial infections due to its noninvasiveness, site-confined irradiation, and high-tissue-penetrating capability. However, the ineffective accumulation of sonosensitizers...

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Veröffentlicht in:	ACS nano 2020-02, Vol.14 (2), p.2063-2076
Hauptverfasser:	Sun, Duo, Pang, Xin, Cheng, Yi, Ming, Jiang, Xiang, Sijin, Zhang, Chang, Lv, Peng, Chu, Chengchao, Chen, Xiaolan, Liu, Gang, Zheng, Nanfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Cell Survival - drug effects Drug Resistance, Multiple, Bacterial - drug effects Male Methicillin-Resistant Staphylococcus aureus - drug effects Mice Mice, Inbred BALB C Microbial Sensitivity Tests Optical Imaging Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Palladium - chemistry Palladium - pharmacology Particle Size Platinum - chemistry Platinum - pharmacology Porphyrins - chemistry Porphyrins - pharmacology Reactive Oxygen Species - metabolism Staphylococcal Infections - drug therapy Staphylococcal Infections - metabolism Surface Properties Ultrasonic Therapy Ultrasonic Waves
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