Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application
The abuse of traditional antibiotics has caused a series of health problems including antimicrobial resistance, which threatens human health. Therefore, searching for broad sources of antimicrobial agents and developing multidimensional strategies to combat bacterial infections are urgent. Here, we...
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Veröffentlicht in: | ACS nano 2019-06, Vol.13 (6), p.6770-6781 |
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creator | Li, Tong Wang, Penglong Guo, Wenbo Huang, Xuemei Tian, Xuehao Wu, Gaorong Xu, Bing Li, Feifei Yan, Cong Liang, Xing-Jie Lei, Haimin |
description | The abuse of traditional antibiotics has caused a series of health problems including antimicrobial resistance, which threatens human health. Therefore, searching for broad sources of antimicrobial agents and developing multidimensional strategies to combat bacterial infections are urgent. Here, we reported two natural self-assembling modes between berberine (BBR) and flavonoid glycosides: nanoparticles (NPs) and nanofibers (NFs), which were both mainly governed by electrostatic and hydrophobic interactions. These two nanostructures exhibited different antibacterial properties from BBR. NPs showed significantly enhanced bacteriostatic activity, whereas NFs displayed a much weaker effect than BBR. The distinguishing properties can be attributed to the different spatial configurations and self-assembly processes of NPs and NFs. Flavonoid glycosides and BBR first formed a one-dimensional complex unit and subsequently self-assembled into three-dimensional nanostructures. With the hydrophilic glucuronic acid toward the outside, NPs exhibited stronger affinity to bacteria, thereby inducing the collapse of the bacteria population and the decrease in biofilm. In addition, in vitro hemolysis tests, cytotoxicity tests, and in vivo zebrafish toxicity evaluation showed that the obtained self-assemblies had good biocompatibility. This supramolecular self-assembly strategy can be applied to construct other nanoscale antibacterial drugs and thus provides weapons for the development of self-delivering drugs in bacterial infection treatment. |
doi_str_mv | 10.1021/acsnano.9b01346 |
format | Article |
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Therefore, searching for broad sources of antimicrobial agents and developing multidimensional strategies to combat bacterial infections are urgent. Here, we reported two natural self-assembling modes between berberine (BBR) and flavonoid glycosides: nanoparticles (NPs) and nanofibers (NFs), which were both mainly governed by electrostatic and hydrophobic interactions. These two nanostructures exhibited different antibacterial properties from BBR. NPs showed significantly enhanced bacteriostatic activity, whereas NFs displayed a much weaker effect than BBR. The distinguishing properties can be attributed to the different spatial configurations and self-assembly processes of NPs and NFs. Flavonoid glycosides and BBR first formed a one-dimensional complex unit and subsequently self-assembled into three-dimensional nanostructures. With the hydrophilic glucuronic acid toward the outside, NPs exhibited stronger affinity to bacteria, thereby inducing the collapse of the bacteria population and the decrease in biofilm. In addition, in vitro hemolysis tests, cytotoxicity tests, and in vivo zebrafish toxicity evaluation showed that the obtained self-assemblies had good biocompatibility. This supramolecular self-assembly strategy can be applied to construct other nanoscale antibacterial drugs and thus provides weapons for the development of self-delivering drugs in bacterial infection treatment.</description><identifier>ISSN: 1936-0851</identifier><identifier>EISSN: 1936-086X</identifier><identifier>DOI: 10.1021/acsnano.9b01346</identifier><identifier>PMID: 31135129</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><ispartof>ACS nano, 2019-06, Vol.13 (6), p.6770-6781</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a333t-6cc7619dd339706ede4ba8a7a3825c6c83039aaff7fc9584ac4af12811b339d3</citedby><cites>FETCH-LOGICAL-a333t-6cc7619dd339706ede4ba8a7a3825c6c83039aaff7fc9584ac4af12811b339d3</cites><orcidid>0000-0002-4793-1705</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsnano.9b01346$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsnano.9b01346$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31135129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Tong</creatorcontrib><creatorcontrib>Wang, Penglong</creatorcontrib><creatorcontrib>Guo, Wenbo</creatorcontrib><creatorcontrib>Huang, Xuemei</creatorcontrib><creatorcontrib>Tian, Xuehao</creatorcontrib><creatorcontrib>Wu, Gaorong</creatorcontrib><creatorcontrib>Xu, Bing</creatorcontrib><creatorcontrib>Li, Feifei</creatorcontrib><creatorcontrib>Yan, Cong</creatorcontrib><creatorcontrib>Liang, Xing-Jie</creatorcontrib><creatorcontrib>Lei, Haimin</creatorcontrib><title>Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application</title><title>ACS nano</title><addtitle>ACS Nano</addtitle><description>The abuse of traditional antibiotics has caused a series of health problems including antimicrobial resistance, which threatens human health. Therefore, searching for broad sources of antimicrobial agents and developing multidimensional strategies to combat bacterial infections are urgent. Here, we reported two natural self-assembling modes between berberine (BBR) and flavonoid glycosides: nanoparticles (NPs) and nanofibers (NFs), which were both mainly governed by electrostatic and hydrophobic interactions. These two nanostructures exhibited different antibacterial properties from BBR. NPs showed significantly enhanced bacteriostatic activity, whereas NFs displayed a much weaker effect than BBR. The distinguishing properties can be attributed to the different spatial configurations and self-assembly processes of NPs and NFs. Flavonoid glycosides and BBR first formed a one-dimensional complex unit and subsequently self-assembled into three-dimensional nanostructures. With the hydrophilic glucuronic acid toward the outside, NPs exhibited stronger affinity to bacteria, thereby inducing the collapse of the bacteria population and the decrease in biofilm. In addition, in vitro hemolysis tests, cytotoxicity tests, and in vivo zebrafish toxicity evaluation showed that the obtained self-assemblies had good biocompatibility. This supramolecular self-assembly strategy can be applied to construct other nanoscale antibacterial drugs and thus provides weapons for the development of self-delivering drugs in bacterial infection treatment.</description><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kL1PwzAQxS0EoqUws6HsKK0dJ04yphFQpLYsHdii85fqKnUiOxHiv8eopRvT3fne7531EHokeE5wQhYgvAXbzUuOCU3ZFZqSkrIYF-zz-tJnZILuvD9gnOVFzm7RhBJCM5KUU2S3MIwO2mipHFfOWBUvwSsZ1fvQexWtwnu0UdKIMEeV9-rI27DfhrN-cKMIuPLRlxn20aaTRpuwrOxgOIghGAbrqu9bI2Awnb1HNxparx7OdYZ2ry-7ehWvP97e62odA6V0iJkQOSOllJSWOWZKqpRDATnQIskEEwXFtATQOteizIoURAqaJAUhPBCSztDiZCtc571TuumdOYL7bghufoNrzsE15-AC8XQi-pEflbzo_5IKgueTIJDNoRudDf__1-4HLjB7rA</recordid><startdate>20190625</startdate><enddate>20190625</enddate><creator>Li, Tong</creator><creator>Wang, Penglong</creator><creator>Guo, Wenbo</creator><creator>Huang, Xuemei</creator><creator>Tian, Xuehao</creator><creator>Wu, Gaorong</creator><creator>Xu, Bing</creator><creator>Li, Feifei</creator><creator>Yan, Cong</creator><creator>Liang, Xing-Jie</creator><creator>Lei, Haimin</creator><general>American Chemical Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-4793-1705</orcidid></search><sort><creationdate>20190625</creationdate><title>Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application</title><author>Li, Tong ; Wang, Penglong ; Guo, Wenbo ; Huang, Xuemei ; Tian, Xuehao ; Wu, Gaorong ; Xu, Bing ; Li, Feifei ; Yan, Cong ; Liang, Xing-Jie ; Lei, Haimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a333t-6cc7619dd339706ede4ba8a7a3825c6c83039aaff7fc9584ac4af12811b339d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Tong</creatorcontrib><creatorcontrib>Wang, Penglong</creatorcontrib><creatorcontrib>Guo, Wenbo</creatorcontrib><creatorcontrib>Huang, Xuemei</creatorcontrib><creatorcontrib>Tian, Xuehao</creatorcontrib><creatorcontrib>Wu, Gaorong</creatorcontrib><creatorcontrib>Xu, Bing</creatorcontrib><creatorcontrib>Li, Feifei</creatorcontrib><creatorcontrib>Yan, Cong</creatorcontrib><creatorcontrib>Liang, Xing-Jie</creatorcontrib><creatorcontrib>Lei, Haimin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Tong</au><au>Wang, Penglong</au><au>Guo, Wenbo</au><au>Huang, Xuemei</au><au>Tian, Xuehao</au><au>Wu, Gaorong</au><au>Xu, Bing</au><au>Li, Feifei</au><au>Yan, Cong</au><au>Liang, Xing-Jie</au><au>Lei, Haimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2019-06-25</date><risdate>2019</risdate><volume>13</volume><issue>6</issue><spage>6770</spage><epage>6781</epage><pages>6770-6781</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>The abuse of traditional antibiotics has caused a series of health problems including antimicrobial resistance, which threatens human health. Therefore, searching for broad sources of antimicrobial agents and developing multidimensional strategies to combat bacterial infections are urgent. Here, we reported two natural self-assembling modes between berberine (BBR) and flavonoid glycosides: nanoparticles (NPs) and nanofibers (NFs), which were both mainly governed by electrostatic and hydrophobic interactions. These two nanostructures exhibited different antibacterial properties from BBR. NPs showed significantly enhanced bacteriostatic activity, whereas NFs displayed a much weaker effect than BBR. The distinguishing properties can be attributed to the different spatial configurations and self-assembly processes of NPs and NFs. Flavonoid glycosides and BBR first formed a one-dimensional complex unit and subsequently self-assembled into three-dimensional nanostructures. With the hydrophilic glucuronic acid toward the outside, NPs exhibited stronger affinity to bacteria, thereby inducing the collapse of the bacteria population and the decrease in biofilm. In addition, in vitro hemolysis tests, cytotoxicity tests, and in vivo zebrafish toxicity evaluation showed that the obtained self-assemblies had good biocompatibility. This supramolecular self-assembly strategy can be applied to construct other nanoscale antibacterial drugs and thus provides weapons for the development of self-delivering drugs in bacterial infection treatment.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>31135129</pmid><doi>10.1021/acsnano.9b01346</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4793-1705</orcidid></addata></record> |
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title | Natural Berberine-Based Chinese Herb Medicine Assembled Nanostructures with Modified Antibacterial Application |
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