Characterizing the Effect of Multivalent Conjugates Composed of Aβ-Specific Ligands and Metal Nanoparticles on Neurotoxic Fibrillar Aggregation

Therapeutically active small molecules represent promising nonimmunogenic alternatives to antibodies for specifically targeting disease-relevant receptors. However, a potential drawback compared to antibody–antigen interactions may be the lower affinity of small molecules toward receptors. Here, we...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS nano 2016-08, Vol.10 (8), p.7582-7597
Hauptverfasser:	Streich, Carmen, Akkari, Laura, Decker, Christina, Bormann, Jenny, Rehbock, Christoph, Müller-Schiffmann, Andreas, Niemeyer, Felix Carlsson, Nagel-Steger, Luitgard, Willbold, Dieter, Sacca, Barbara, Korth, Carsten, Schrader, Thomas, Barcikowski, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - diagnosis Alzheimer Disease - therapy Amyloid beta-Peptides - chemistry Gold Ligands Metal Nanoparticles Peptide Fragments
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!