Highly Catalytic Nanodots with Renal Clearance for Radiation Protection
Ionizing radiation (gamma and X-ray) is widely used in industry and medicine, but it can also pose a significant hazardous effect on health and induce cancer, physical deformity, and even death, due to DNA damage and invasion of free radicals. There is therefore an urgent unmet demand in designing h...
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| Veröffentlicht in: | ACS nano 2016-04, Vol.10 (4), p.4511-4519 |
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| creator | Zhang, Xiao-Dong Zhang, Jinxuan Wang, Junying Yang, Jiang Chen, Jie Shen, Xiu Deng, Jiao Deng, Dehui Long, Wei Sun, Yuan-Ming Liu, Changlong Li, Meixian |
| description | Ionizing radiation (gamma and X-ray) is widely used in industry and medicine, but it can also pose a significant hazardous effect on health and induce cancer, physical deformity, and even death, due to DNA damage and invasion of free radicals. There is therefore an urgent unmet demand in designing highly efficient radioprotectants with synergetic integration of effective renal clearance and low toxicity. In this study, we designed ultrasmall (sub-5 nm) highly catalytically active and cysteine-protected MoS2 dots as radioprotectants and investigated their application in protection against ionizing radiation. In vivo preclinical studies showed that the surviving fraction of MoS2-treated mice can appreciably increase to up to 79% when they were exposed to high-energy ionizing radiation. Furthermore, MoS2 dots can contribute in cleaning up the accumulated free radicals within the body, repairing DNA damage, and recovering all vital chemical and biochemical indicators, suggesting their unique role as free radical scavengers. MoS2 dots showed rapid and efficient urinary excretion with more than 80% injected dose eliminated from the body after 24 h due to their ultrasmall hydrodynamic size and did not cause any noticeable toxic responses up to 30 days. |
| doi_str_mv | 10.1021/acsnano.6b00321 |
| format | Article |
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There is therefore an urgent unmet demand in designing highly efficient radioprotectants with synergetic integration of effective renal clearance and low toxicity. In this study, we designed ultrasmall (sub-5 nm) highly catalytically active and cysteine-protected MoS2 dots as radioprotectants and investigated their application in protection against ionizing radiation. In vivo preclinical studies showed that the surviving fraction of MoS2-treated mice can appreciably increase to up to 79% when they were exposed to high-energy ionizing radiation. Furthermore, MoS2 dots can contribute in cleaning up the accumulated free radicals within the body, repairing DNA damage, and recovering all vital chemical and biochemical indicators, suggesting their unique role as free radical scavengers. MoS2 dots showed rapid and efficient urinary excretion with more than 80% injected dose eliminated from the body after 24 h due to their ultrasmall hydrodynamic size and did not cause any noticeable toxic responses up to 30 days.</description><identifier>ISSN: 1936-0851</identifier><identifier>EISSN: 1936-086X</identifier><identifier>DOI: 10.1021/acsnano.6b00321</identifier><identifier>PMID: 27018632</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>3T3 Cells ; Animals ; Catalysis ; Cell Survival ; Cysteine - chemistry ; Disulfides - chemistry ; DNA Damage ; Free Radical Scavengers - chemistry ; Free Radical Scavengers - pharmacokinetics ; Free Radicals - metabolism ; Humans ; Kidney - drug effects ; Kidney - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Molybdenum - chemistry ; Nanoparticles - chemistry ; Nanoparticles - metabolism ; Particle Size ; Radiation Protection - methods ; Radiation, Ionizing ; Radiation-Protective Agents - chemistry ; Radiation-Protective Agents - pharmacokinetics ; Renal Reabsorption ; Surface Properties</subject><ispartof>ACS nano, 2016-04, Vol.10 (4), p.4511-4519</ispartof><rights>Copyright © 2016 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a333t-b85c9eb648d36d8745f34d799be26f0a3e0302392a53b600092c06a83cde5fd53</citedby><cites>FETCH-LOGICAL-a333t-b85c9eb648d36d8745f34d799be26f0a3e0302392a53b600092c06a83cde5fd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsnano.6b00321$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsnano.6b00321$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27018632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xiao-Dong</creatorcontrib><creatorcontrib>Zhang, Jinxuan</creatorcontrib><creatorcontrib>Wang, Junying</creatorcontrib><creatorcontrib>Yang, Jiang</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Shen, Xiu</creatorcontrib><creatorcontrib>Deng, Jiao</creatorcontrib><creatorcontrib>Deng, Dehui</creatorcontrib><creatorcontrib>Long, Wei</creatorcontrib><creatorcontrib>Sun, Yuan-Ming</creatorcontrib><creatorcontrib>Liu, Changlong</creatorcontrib><creatorcontrib>Li, Meixian</creatorcontrib><title>Highly Catalytic Nanodots with Renal Clearance for Radiation Protection</title><title>ACS nano</title><addtitle>ACS Nano</addtitle><description>Ionizing radiation (gamma and X-ray) is widely used in industry and medicine, but it can also pose a significant hazardous effect on health and induce cancer, physical deformity, and even death, due to DNA damage and invasion of free radicals. There is therefore an urgent unmet demand in designing highly efficient radioprotectants with synergetic integration of effective renal clearance and low toxicity. In this study, we designed ultrasmall (sub-5 nm) highly catalytically active and cysteine-protected MoS2 dots as radioprotectants and investigated their application in protection against ionizing radiation. In vivo preclinical studies showed that the surviving fraction of MoS2-treated mice can appreciably increase to up to 79% when they were exposed to high-energy ionizing radiation. Furthermore, MoS2 dots can contribute in cleaning up the accumulated free radicals within the body, repairing DNA damage, and recovering all vital chemical and biochemical indicators, suggesting their unique role as free radical scavengers. MoS2 dots showed rapid and efficient urinary excretion with more than 80% injected dose eliminated from the body after 24 h due to their ultrasmall hydrodynamic size and did not cause any noticeable toxic responses up to 30 days.</description><subject>3T3 Cells</subject><subject>Animals</subject><subject>Catalysis</subject><subject>Cell Survival</subject><subject>Cysteine - chemistry</subject><subject>Disulfides - chemistry</subject><subject>DNA Damage</subject><subject>Free Radical Scavengers - chemistry</subject><subject>Free Radical Scavengers - pharmacokinetics</subject><subject>Free Radicals - metabolism</subject><subject>Humans</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molybdenum - chemistry</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - metabolism</subject><subject>Particle Size</subject><subject>Radiation Protection - methods</subject><subject>Radiation, Ionizing</subject><subject>Radiation-Protective Agents - chemistry</subject><subject>Radiation-Protective Agents - pharmacokinetics</subject><subject>Renal Reabsorption</subject><subject>Surface Properties</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFLwzAUxoMoTqdnb5K7dHtJljQ9StFNGCpDwVt5TVLX0TUj6ZD993Zs7ubpfYfv98H7EXLHYMSAszGa2GLrR6oEEJydkSuWCZWAVl_npyzZgFzHuAKQqU7VJRnwFJhWgl-R6az-XjY7mmOHza6rDX3t96zvIv2puyVduBYbmjcOA7bG0coHukBbY1f7lr4H3zmzjzfkosImutvjHZLP56ePfJbM36Yv-eM8QSFEl5RamsyVaqKtUFanE1mJiU2zrHRcVYDCgQAuMo5SlAoAMm5AoRbGOllZKYZkfNg1wccYXFVsQr3GsCsYFHslxVFJcVTSE_cHYrMt186e-n8O-sLDodCTxcpvQ_9x_HfuF1a0bHY</recordid><startdate>20160426</startdate><enddate>20160426</enddate><creator>Zhang, Xiao-Dong</creator><creator>Zhang, Jinxuan</creator><creator>Wang, Junying</creator><creator>Yang, Jiang</creator><creator>Chen, Jie</creator><creator>Shen, Xiu</creator><creator>Deng, Jiao</creator><creator>Deng, Dehui</creator><creator>Long, Wei</creator><creator>Sun, Yuan-Ming</creator><creator>Liu, Changlong</creator><creator>Li, Meixian</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20160426</creationdate><title>Highly Catalytic Nanodots with Renal Clearance for Radiation Protection</title><author>Zhang, Xiao-Dong ; Zhang, Jinxuan ; Wang, Junying ; Yang, Jiang ; Chen, Jie ; Shen, Xiu ; Deng, Jiao ; Deng, Dehui ; Long, Wei ; Sun, Yuan-Ming ; Liu, Changlong ; Li, Meixian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a333t-b85c9eb648d36d8745f34d799be26f0a3e0302392a53b600092c06a83cde5fd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>3T3 Cells</topic><topic>Animals</topic><topic>Catalysis</topic><topic>Cell Survival</topic><topic>Cysteine - chemistry</topic><topic>Disulfides - chemistry</topic><topic>DNA Damage</topic><topic>Free Radical Scavengers - chemistry</topic><topic>Free Radical Scavengers - pharmacokinetics</topic><topic>Free Radicals - metabolism</topic><topic>Humans</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molybdenum - chemistry</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - metabolism</topic><topic>Particle Size</topic><topic>Radiation Protection - methods</topic><topic>Radiation, Ionizing</topic><topic>Radiation-Protective Agents - chemistry</topic><topic>Radiation-Protective Agents - pharmacokinetics</topic><topic>Renal Reabsorption</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiao-Dong</creatorcontrib><creatorcontrib>Zhang, Jinxuan</creatorcontrib><creatorcontrib>Wang, Junying</creatorcontrib><creatorcontrib>Yang, Jiang</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Shen, Xiu</creatorcontrib><creatorcontrib>Deng, Jiao</creatorcontrib><creatorcontrib>Deng, Dehui</creatorcontrib><creatorcontrib>Long, Wei</creatorcontrib><creatorcontrib>Sun, Yuan-Ming</creatorcontrib><creatorcontrib>Liu, Changlong</creatorcontrib><creatorcontrib>Li, Meixian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiao-Dong</au><au>Zhang, Jinxuan</au><au>Wang, Junying</au><au>Yang, Jiang</au><au>Chen, Jie</au><au>Shen, Xiu</au><au>Deng, Jiao</au><au>Deng, Dehui</au><au>Long, Wei</au><au>Sun, Yuan-Ming</au><au>Liu, Changlong</au><au>Li, Meixian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly Catalytic Nanodots with Renal Clearance for Radiation Protection</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2016-04-26</date><risdate>2016</risdate><volume>10</volume><issue>4</issue><spage>4511</spage><epage>4519</epage><pages>4511-4519</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>Ionizing radiation (gamma and X-ray) is widely used in industry and medicine, but it can also pose a significant hazardous effect on health and induce cancer, physical deformity, and even death, due to DNA damage and invasion of free radicals. There is therefore an urgent unmet demand in designing highly efficient radioprotectants with synergetic integration of effective renal clearance and low toxicity. In this study, we designed ultrasmall (sub-5 nm) highly catalytically active and cysteine-protected MoS2 dots as radioprotectants and investigated their application in protection against ionizing radiation. In vivo preclinical studies showed that the surviving fraction of MoS2-treated mice can appreciably increase to up to 79% when they were exposed to high-energy ionizing radiation. Furthermore, MoS2 dots can contribute in cleaning up the accumulated free radicals within the body, repairing DNA damage, and recovering all vital chemical and biochemical indicators, suggesting their unique role as free radical scavengers. MoS2 dots showed rapid and efficient urinary excretion with more than 80% injected dose eliminated from the body after 24 h due to their ultrasmall hydrodynamic size and did not cause any noticeable toxic responses up to 30 days.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>27018632</pmid><doi>10.1021/acsnano.6b00321</doi><tpages>9</tpages></addata></record> |
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| source | ACS Publications; MEDLINE |
| subjects | 3T3 Cells Animals Catalysis Cell Survival Cysteine - chemistry Disulfides - chemistry DNA Damage Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacokinetics Free Radicals - metabolism Humans Kidney - drug effects Kidney - metabolism Male Mice Mice, Inbred C57BL Molybdenum - chemistry Nanoparticles - chemistry Nanoparticles - metabolism Particle Size Radiation Protection - methods Radiation, Ionizing Radiation-Protective Agents - chemistry Radiation-Protective Agents - pharmacokinetics Renal Reabsorption Surface Properties |
| title | Highly Catalytic Nanodots with Renal Clearance for Radiation Protection |
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