Cholinergic Neuron Targeting Nanosystem Delivering Hybrid Peptide for Combinatorial Mitochondrial Therapy in Alzheimer’s Disease

Mitochondrial dysfunction in neurons has recently become a promising therapeutic target for Alzheimer’s disease (AD). Regulation of dysfunctional mitochondria through multiple pathways rather than antioxidation monotherapy indicates synergistic therapeutic effects. Therefore, we developed a multifun...

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Veröffentlicht in:	ACS nano 2022-07, Vol.16 (7), p.11455-11472
Hauptverfasser:	Qian, Kang, Bao, Xiaoyan, Li, Yixian, Wang, Pengzhen, Guo, Qian, Yang, Peng, Xu, Shuting, Yu, Fazhi, Meng, Ran, Cheng, Yunlong, Sheng, Dongyu, Cao, Jinxu, Xu, Minjun, Wu, Jing, Wang, Tianying, Wang, Yonghui, Xie, Qiong, Lu, Wei, Zhang, Qizhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Amyloid beta-Peptides - metabolism Animals Brain - metabolism Cholinergic Neurons - metabolism Mice Mitochondria Peptides - chemistry
Online-Zugang:	Volltext
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