Nanostructured Organosilica Nitric Oxide Donors Intrinsically Regulate Macrophage Polarization with Antitumor Effect
Nitric oxide (NO) has many important biological functions; however, it has been a long-standing challenge to utilize the exogenous NO donor itself in the activation of macrophages for cancer immunotherapy. Herein, we report the synthesis of a nanoparticle-based NO delivery platform with a rational d...
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| Veröffentlicht in: | ACS nano 2022-07, Vol.16 (7), p.10943-10957 |
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| container_title | ACS nano |
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| creator | Theivendran, Shevanuja Gu, Zhengying Tang, Jie Yang, Yannan Song, Hao Yang, Yang Zhang, Min Cheng, Dan Yu, Chengzhong |
| description | Nitric oxide (NO) has many important biological functions; however, it has been a long-standing challenge to utilize the exogenous NO donor itself in the activation of macrophages for cancer immunotherapy. Herein, we report the synthesis of a nanoparticle-based NO delivery platform with a rational design for effective NO delivery and macrophage activation. S-Nitrosothiol (SNO) modified organosilica nanoparticles with a tetrasulfide-containing composition produced a higher level of intracellular NO than their bare silica counterparts in macrophages. Enhanced intracellular delivery of NO resulted in mitochondrial dysfunction and disruption of the tricarboxylic acid cycle, leading to macrophage activation and delayed tumor growth. This study provides insights on intracellularly delivered NO for regulating the polarization of macrophages and cancer immunotherapy. |
| doi_str_mv | 10.1021/acsnano.2c03348 |
| format | Article |
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Herein, we report the synthesis of a nanoparticle-based NO delivery platform with a rational design for effective NO delivery and macrophage activation. S-Nitrosothiol (SNO) modified organosilica nanoparticles with a tetrasulfide-containing composition produced a higher level of intracellular NO than their bare silica counterparts in macrophages. Enhanced intracellular delivery of NO resulted in mitochondrial dysfunction and disruption of the tricarboxylic acid cycle, leading to macrophage activation and delayed tumor growth. This study provides insights on intracellularly delivered NO for regulating the polarization of macrophages and cancer immunotherapy.</description><identifier>ISSN: 1936-0851</identifier><identifier>EISSN: 1936-086X</identifier><identifier>DOI: 10.1021/acsnano.2c03348</identifier><identifier>PMID: 35735363</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Humans ; Macrophage Activation ; Macrophages ; Nanoparticles ; Neoplasms ; Nitric Oxide ; Nitric Oxide Donors - pharmacology ; Silicon Dioxide - pharmacology</subject><ispartof>ACS nano, 2022-07, Vol.16 (7), p.10943-10957</ispartof><rights>2022 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a263t-d936de64d7a88955d30ee3e13f75206a8a6f8cf0f268854d25fe7977774711b13</citedby><cites>FETCH-LOGICAL-a263t-d936de64d7a88955d30ee3e13f75206a8a6f8cf0f268854d25fe7977774711b13</cites><orcidid>0000-0002-6383-0605 ; 0000-0003-3707-0785</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsnano.2c03348$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsnano.2c03348$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35735363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Theivendran, Shevanuja</creatorcontrib><creatorcontrib>Gu, Zhengying</creatorcontrib><creatorcontrib>Tang, Jie</creatorcontrib><creatorcontrib>Yang, Yannan</creatorcontrib><creatorcontrib>Song, Hao</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Cheng, Dan</creatorcontrib><creatorcontrib>Yu, Chengzhong</creatorcontrib><title>Nanostructured Organosilica Nitric Oxide Donors Intrinsically Regulate Macrophage Polarization with Antitumor Effect</title><title>ACS nano</title><addtitle>ACS Nano</addtitle><description>Nitric oxide (NO) has many important biological functions; however, it has been a long-standing challenge to utilize the exogenous NO donor itself in the activation of macrophages for cancer immunotherapy. 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This study provides insights on intracellularly delivered NO for regulating the polarization of macrophages and cancer immunotherapy.</description><subject>Humans</subject><subject>Macrophage Activation</subject><subject>Macrophages</subject><subject>Nanoparticles</subject><subject>Neoplasms</subject><subject>Nitric Oxide</subject><subject>Nitric Oxide Donors - pharmacology</subject><subject>Silicon Dioxide - pharmacology</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UE1PAjEQbYxGED17M72bhXZLPzgSRCVBMEYTb5uybaFk6ZK2G8VfbwnIzbnMZOa9lzcPgFuMuhjluCfL4KSru3mJCOmLM9DGA8IyJNjn-WmmuAWuQlgjRLng7BK0COWEEkbaIM4SPUTflLHxWsG5X-4XtrKlhDMbvS3h_NsqDR9qV_sAJy7tXEjnqtrBN71sKhk1fJGlr7crudTwta6ktz8y2trBLxtXcOiijc2m9nBsjC7jNbgwsgr65tg74ONx_D56zqbzp8loOM1kzkjMVLKvNOsrLoUYUKoI0ppoTAynOWJSSGZEaZDJmRC0r3JqNB_wVH2O8QKTDugddJO3ELw2xdbbjfS7AqNin19xzK845pcYdwfGtllstDrh_wJLgPsDIDGLdd14lx74V-4X7f9-ZA</recordid><startdate>20220726</startdate><enddate>20220726</enddate><creator>Theivendran, Shevanuja</creator><creator>Gu, Zhengying</creator><creator>Tang, Jie</creator><creator>Yang, Yannan</creator><creator>Song, Hao</creator><creator>Yang, Yang</creator><creator>Zhang, Min</creator><creator>Cheng, Dan</creator><creator>Yu, Chengzhong</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-6383-0605</orcidid><orcidid>https://orcid.org/0000-0003-3707-0785</orcidid></search><sort><creationdate>20220726</creationdate><title>Nanostructured Organosilica Nitric Oxide Donors Intrinsically Regulate Macrophage Polarization with Antitumor Effect</title><author>Theivendran, Shevanuja ; Gu, Zhengying ; Tang, Jie ; Yang, Yannan ; Song, Hao ; Yang, Yang ; Zhang, Min ; Cheng, Dan ; Yu, Chengzhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a263t-d936de64d7a88955d30ee3e13f75206a8a6f8cf0f268854d25fe7977774711b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Humans</topic><topic>Macrophage Activation</topic><topic>Macrophages</topic><topic>Nanoparticles</topic><topic>Neoplasms</topic><topic>Nitric Oxide</topic><topic>Nitric Oxide Donors - pharmacology</topic><topic>Silicon Dioxide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Theivendran, Shevanuja</creatorcontrib><creatorcontrib>Gu, Zhengying</creatorcontrib><creatorcontrib>Tang, Jie</creatorcontrib><creatorcontrib>Yang, Yannan</creatorcontrib><creatorcontrib>Song, Hao</creatorcontrib><creatorcontrib>Yang, Yang</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><creatorcontrib>Cheng, Dan</creatorcontrib><creatorcontrib>Yu, Chengzhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Theivendran, Shevanuja</au><au>Gu, Zhengying</au><au>Tang, Jie</au><au>Yang, Yannan</au><au>Song, Hao</au><au>Yang, Yang</au><au>Zhang, Min</au><au>Cheng, Dan</au><au>Yu, Chengzhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanostructured Organosilica Nitric Oxide Donors Intrinsically Regulate Macrophage Polarization with Antitumor Effect</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2022-07-26</date><risdate>2022</risdate><volume>16</volume><issue>7</issue><spage>10943</spage><epage>10957</epage><pages>10943-10957</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>Nitric oxide (NO) has many important biological functions; however, it has been a long-standing challenge to utilize the exogenous NO donor itself in the activation of macrophages for cancer immunotherapy. 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| issn | 1936-0851 1936-086X |
| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Humans Macrophage Activation Macrophages Nanoparticles Neoplasms Nitric Oxide Nitric Oxide Donors - pharmacology Silicon Dioxide - pharmacology |
| title | Nanostructured Organosilica Nitric Oxide Donors Intrinsically Regulate Macrophage Polarization with Antitumor Effect |
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