Imaging Strategy that Achieves Ultrahigh Contrast by Utilizing Differential Esterase Activity in Organs: Application in Early Detection of Pancreatic Cancer

Most nanoparticles show much higher uptake in mononuclear phagocyte system (MPS) organs than in tumors, which has been a long-lasting dilemma in nanomedicine. Here, we report an imaging strategy that selectively decreases MPS organ uptakes by utilizing the differential esterase activity in tumors an...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS nano 2021-11, Vol.15 (11), p.17348-17360
Hauptverfasser:	Lee, Woonghee, Il An, Gwang, Park, Hyun, Sarkar, Swarbhanu, Ha, Yeong Su, Huynh, Phuong Tu, Bhise, Abhinav, Bhatt, Nikunj, Ahn, Heesu, Pandya, Darpan N., Kim, Jung Young, Kim, Seokho, Jun, Eunsung, Kim, Song Cheol, Lee, Kyo Chul, Yoo, Jeongsoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Esterases Humans Liposomes Pancreatic Neoplasms Pancreatic Neoplasms - diagnostic imaging Positron-Emission Tomography - methods Tissue Distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!