Hybrid Nanosystems for Biomedical Applications

Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy at overcoming obstacles not readily surmounted by nonhybridized counterparts. Currently, hybrid nanosystems are implemented for gene therapy, drug delivery, and phototherapy in addition to tissue...

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Veröffentlicht in:ACS nano 2021-02, Vol.15 (2), p.2099-2142
Hauptverfasser: Seaberg, Joshua, Montazerian, Hossein, Hossen, Md Nazir, Bhattacharya, Resham, Khademhosseini, Ali, Mukherjee, Priyabrata
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container_end_page 2142
container_issue 2
container_start_page 2099
container_title ACS nano
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creator Seaberg, Joshua
Montazerian, Hossein
Hossen, Md Nazir
Bhattacharya, Resham
Khademhosseini, Ali
Mukherjee, Priyabrata
description Inorganic/organic hybrid nanosystems have been increasingly developed for their versatility and efficacy at overcoming obstacles not readily surmounted by nonhybridized counterparts. Currently, hybrid nanosystems are implemented for gene therapy, drug delivery, and phototherapy in addition to tissue regeneration, vaccines, antibacterials, biomolecule detection, imaging probes, and theranostics. Though diverse, these nanosystems can be classified according to foundational inorganic/organic components, accessory moieties, and architecture of hybridization. Within this Review, we begin by providing a historical context for the development of biomedical hybrid nanosystems before describing the properties, synthesis, and characterization of their component building blocks. Afterward, we introduce the architectures of hybridization and highlight recent biomedical nanosystem developments by area of application, emphasizing hybrids of distinctive utility and innovation. Finally, we draw attention to ongoing clinical trials before recapping our discussion of hybrid nanosystems and providing a perspective on the future of the field.
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subjects Drug Delivery Systems
Phototherapy
title Hybrid Nanosystems for Biomedical Applications
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