Identifying New AMP-Activated Protein Kinase Inhibitors That Protect against Ischemic Brain Injury

We recently reported that AMP-activated protein kinase (AMPK) contributes to zinc-induced neuronal death by inducing Bim, a pro-apoptotic Bcl-2 homology domain 3-only protein, in a liver kinase B1 (LKB1)-dependent manner. Current data suggest AMPK plays key roles in excitotoxicity and ischemic brain...

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Veröffentlicht in:	ACS chemical neuroscience 2019-05, Vol.10 (5), p.2345-2354
Hauptverfasser:	Eom, Jae-Won, Kim, Tae-Youn, Seo, Bo-Ra, Park, Hwangseo, Koh, Jae-Young, Kim, Yang-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - metabolism Animals Apoptosis - drug effects Brain Ischemia - prevention & control Disease Models, Animal Drug Discovery Infarction, Middle Cerebral Artery Inhibitory Concentration 50 Mice Protein Kinase Inhibitors - isolation & purification Protein Kinase Inhibitors - pharmacology Rats
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