A Novel M 1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

Selective activation of the M subtype of muscarinic acetylcholine receptor, via positive allosteric modulation (PAM), is an exciting strategy to improve cognition in schizophrenia and Alzheimer's disease patients. However, highly potent M ago-PAMs, such as MK-7622, PF-06764427, and PF-06827443,...

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Veröffentlicht in:	ACS chemical neuroscience 2018-09, Vol.9 (9), p.2274-2285
Hauptverfasser:	Rook, Jerri M, Bertron, Jeanette L, Cho, Hyekyung P, Garcia-Barrantes, Pedro M, Moran, Sean P, Maksymetz, James T, Nance, Kellie D, Dickerson, Jonathan W, Remke, Daniel H, Chang, Sichen, Harp, Joel M, Blobaum, Anna L, Niswender, Colleen M, Jones, Carrie K, Stauffer, Shaun R, Conn, P Jeffrey, Lindsley, Craig W
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animals Antipsychotic Agents - toxicity CHO Cells Cognition - drug effects Cognitive Dysfunction - chemically induced Cognitive Dysfunction - physiopathology Conditioning, Psychological - drug effects Cricetulus Exploratory Behavior - drug effects Fear Mice Morpholines - pharmacology Morpholines - toxicity Prefrontal Cortex - drug effects Pyrazoles - pharmacology Pyrazoles - toxicity Rats Risperidone - toxicity Seizures - chemically induced
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