Comparison of α‑Synuclein Fibril Inhibition by Four Different Amyloid Inhibitors

Aggregation of α-synuclein (α-Syn) into toxic oligomers and fibrils leads to Parkinson’s disease (PD) pathogenesis. Molecules that can inhibit the fibrillization and oligomerization of α-Syn have potential therapeutic value. Here, we studied four selective amyloid inhibitors: dopamine (Dopa), amphot...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS chemical neuroscience 2017-12, Vol.8 (12), p.2722-2733
Hauptverfasser:	Jha, Narendra Nath, Kumar, Rakesh, Panigrahi, Rajlaxmi, Navalkar, Ambuja, Ghosh, Dhiman, Sahay, Shruti, Mondal, Mritunjoy, Kumar, Ashutosh, Maji, Samir. K
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - antagonists & inhibitors alpha-Synuclein - chemistry alpha-Synuclein - ultrastructure Amphotericin B - chemistry Amyloid - antagonists & inhibitors Amyloid - ultrastructure Binding Sites Catechin - analogs & derivatives Catechin - chemistry Dopamine - chemistry Kinetics Neuroprotective Agents - chemistry Protein Binding
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!