Molecular Pharmacology of Selective Na V 1.6 and Dual Na V 1.6/Na V 1.2 Channel Inhibitors that Suppress Excitatory Neuronal Activity Ex Vivo

Voltage-gated sodium channel (Na ) inhibitors are used to treat neurological disorders of hyperexcitability such as epilepsy. These drugs act by attenuating neuronal action potential firing to reduce excitability in the brain. However, all currently available Na -targeting antiseizure medications no...

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Veröffentlicht in:	ACS chemical neuroscience 2024-03, Vol.15 (6), p.1169-1184
Hauptverfasser:	Goodchild, Samuel J, Shuart, Noah Gregory, Williams, Aaron D, Ye, Wenlei, Parrish, R Ryley, Soriano, Maegan, Thouta, Samrat, Mezeyova, Janette, Waldbrook, Matthew, Dean, Richard, Focken, Thilo, Ghovanloo, Mohammad-Reza, Ruben, Peter C, Scott, Fiona, Cohen, Charles J, Empfield, James, Johnson, J P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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