Structural and Molecular Insight into Piperazine and Piperidine Derivatives as Histamine H 3 and Sigma-1 Receptor Antagonists with Promising Antinociceptive Properties

In an attempt to extend recent studies showing that some clinically evaluated histamine H receptor (H R) antagonists possess nanomolar affinity at sigma-1 receptors (σ R), we selected 20 representative structures among our previously reported H R ligands to investigate their affinity at σRs. Most of...

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Veröffentlicht in:	ACS chemical neuroscience 2022-01, Vol.13 (1), p.1-15
Hauptverfasser:	Szczepańska, Katarzyna, Podlewska, Sabina, Dichiara, Maria, Gentile, Davide, Patamia, Vincenzo, Rosier, Niklas, Mönnich, Denise, Ruiz Cantero, Ma Carmen, Karcz, Tadeusz, Łażewska, Dorota, Siwek, Agata, Pockes, Steffen, Cobos, Enrique J, Marrazzo, Agostino, Stark, Holger, Rescifina, Antonio, Bojarski, Andrzej J, Amata, Emanuele, Kieć-Kononowicz, Katarzyna
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Histamine Histamine Antagonists Histamine H3 Antagonists - pharmacology Ligands Piperazine Piperidines - pharmacology Receptors, Histamine H3 Receptors, sigma Sigma-1 Receptor Structure-Activity Relationship
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