CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity

RUVBL1 and RUVBL2 are ATPases associated with diverse cellular activities (AAAs) that form a complex involved in a variety of cellular processes, including chromatin remodeling and regulation of gene expression. RUVBLs have a strong link to oncogenesis, where overexpression is correlated with tumor...

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Veröffentlicht in:	ACS chemical biology 2019-02, Vol.14 (2), p.236-244
Hauptverfasser:	Assimon, Victoria A, Tang, Yangzhong, Vargas, Jesse D, Lee, Grace J, Wu, Zhi Yong, Lou, Kenny, Yao, Bing, Menon, Mary-Kamala, Pios, Ariel, Perez, Kristy C, Madriaga, Antonett, Buchowiecki, Peter K, Rolfe, Mark, Shawver, Laura, Jiao, Xianyun, Le Moigne, Ronan, Zhou, Han-Jie, Anderson, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology ATPases Associated with Diverse Cellular Activities - antagonists & inhibitors ATPases Associated with Diverse Cellular Activities - genetics ATPases Associated with Diverse Cellular Activities - metabolism Azepines - pharmacology Benzamides - pharmacology Carrier Proteins - antagonists & inhibitors Carrier Proteins - genetics Carrier Proteins - metabolism DNA Helicases - antagonists & inhibitors DNA Helicases - genetics DNA Helicases - metabolism HCT116 Cells Humans Mutation Protein Binding
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