Effects of Histone H2B Ubiquitylations and H3K79me 3 on Transcription Elongation

Post-translational modifications of histone proteins often mediate gene regulation by altering the global and local stability of the nucleosome, the basic gene-packing unit of eukaryotes. We employed semisynthetic approaches to introduce histone H2B ubiquitylations at K34 (H2BK34ub) and K120 (H2BK12...

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Veröffentlicht in:	ACS chemical biology 2023-03, Vol.18 (3), p.537-548
Hauptverfasser:	Huynh, Mai T, Sengupta, Bhaswati, Krajewski, Wladyslaw A, Lee, Tae-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Histones - metabolism Nucleosomes RNA Polymerase II - chemistry Transcription, Genetic Ubiquitination
Online-Zugang:	Volltext
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