Copper-Catalyzed Regioselective Borylfluoromethylation of Alkenes

Copper-Catalyzed Regioselective Borylfluoromethylation of Alkenes

A copper-catalyzed borylfluoromethylation of alkenes with fluoromethyl iodide and diboron reagents was disclosed. This protocol afforded the previously unknown and synthetically useful borylfluoromethylated alkanes in good yields and excellent regioselectivity. Its synthetic application was illustra...

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Veröffentlicht in:ACS catalysis 2019-06, Vol.9 (6), p.5726-5731
Hauptverfasser: Wu, Nuo-Yi, Xu, Xiu-Hua, Qing, Feng-Ling
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creator Wu, Nuo-Yi
Xu, Xiu-Hua
Qing, Feng-Ling
description A copper-catalyzed borylfluoromethylation of alkenes with fluoromethyl iodide and diboron reagents was disclosed. This protocol afforded the previously unknown and synthetically useful borylfluoromethylated alkanes in good yields and excellent regioselectivity. Its synthetic application was illustrated through the derivatization of organoboron products and preparation of monofluorinated ibuprofen.
doi_str_mv 10.1021/acscatal.9b01530
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title Copper-Catalyzed Regioselective Borylfluoromethylation of Alkenes
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