Visible-Light-Mediated Efficient Metal-Free Catalyst for α‑Oxygenation of Tertiary Amines to Amides

Visible-Light-Mediated Efficient Metal-Free Catalyst for α‑Oxygenation of Tertiary Amines to Amides

A metal-free system has been discovered for the efficient α-oxygenation of tertiary amines to the corresponding amides using oxygen as an oxidant. This visible-light-mediated oxygenation reaction exhibited excellent substrates scope under mild reaction conditions and generated water as the only bypr...

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Veröffentlicht in:ACS catalysis 2018-07, Vol.8 (7), p.6659-6664
Hauptverfasser: Zhang, Yu, Riemer, Daniel, Schilling, Waldemar, Kollmann, Jiri, Das, Shoubhik
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container_end_page 6664
container_issue 7
container_start_page 6659
container_title ACS catalysis
container_volume 8
creator Zhang, Yu
Riemer, Daniel
Schilling, Waldemar
Kollmann, Jiri
Das, Shoubhik
description A metal-free system has been discovered for the efficient α-oxygenation of tertiary amines to the corresponding amides using oxygen as an oxidant. This visible-light-mediated oxygenation reaction exhibited excellent substrates scope under mild reaction conditions and generated water as the only byproduct. The synthetic utility of this approach has been demonstrated by applying onto drug molecules. At the end, detailed mechanistic reactions clearly showed the role of oxygen and the photocatalyst.
doi_str_mv 10.1021/acscatal.8b01897
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