A Buried Water Molecule Influences Reactivity in α‑Amylase on a Subnanosecond Time Scale

The subset of catalytically competent conformations can be significantly small in comparison with the full conformational landscape of enzyme–substrate complexes. In some enzymes, the probability of finding a reactive conformation can account for up to 4 kcal/mol of activation barrier, even when the...

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Veröffentlicht in:	ACS catalysis 2018-05, Vol.8 (5), p.4055-4063
Hauptverfasser:	Santos-Martins, Diogo, Calixto, Ana R, Fernandes, Pedro A, Ramos, Maria J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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