Visible-Light-Induced External Oxidant-Free Oxidative Phosphonylation of C(sp2)–H Bonds
Considering the synthetic value of phosphonates, developing powerful catalytic methods for the phosphonylation of C(sp2)–H bonds is important. Herein, we achieve a visible-light-induced external oxidant-free oxidative phosphonylation of C(sp2)–H bonds via the combination of photocatalysis and prot...
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| Veröffentlicht in: | ACS catalysis 2017-11, Vol.7 (11), p.7412-7416 |
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| container_issue | 11 |
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| container_title | ACS catalysis |
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| creator | Niu, Linbin Liu, Jiamei Yi, Hong Wang, Shengchun Liang, Xing-An Singh, Atul K Chiang, Chien-Wei Lei, Aiwen |
| description | Considering the synthetic value of phosphonates, developing powerful catalytic methods for the phosphonylation of C(sp2)–H bonds is important. Herein, we achieve a visible-light-induced external oxidant-free oxidative phosphonylation of C(sp2)–H bonds via the combination of photocatalysis and proton-reduction catalysis. Mechanistic studies indicate that the visible-light-induced electron-rich arene radical cation is the key reactive intermediate. The synthetic application of this approach is demonstrated in the late-stage functionalization of pharmaceutical molecules. This study may have significant implications for the functionalization of C(sp2)–H bonds, especially for those that are sensitive to oxidative conditions. |
| doi_str_mv | 10.1021/acscatal.7b02418 |
| format | Article |
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| source | American Chemical Society Journals |
| title | Visible-Light-Induced External Oxidant-Free Oxidative Phosphonylation of C(sp2)–H Bonds |
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