Computational Assignment of the Histidine Protonation State in (6-4) Photolyase Enzyme and Its Effect on the Protonation Step

The initial step to resolving the controversy regarding the repair mechanism of the pyrimidine (6-4) pyrimidone photoproduct DNA lesion is to determine the protonation state of the two conserved active site histidine residues (His365 and His369 in Drosophila melanogaster) in the (6-4) photolyase enz...

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Veröffentlicht in:	ACS catalysis 2016-08, Vol.6 (8), p.5500-5507
Hauptverfasser:	Dokainish, Hisham M, Kitao, Akio
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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