Substrate Promiscuity and Hyperoxidation Susceptibility as Potential Driving Forces for the Co-evolution of Prx5-Type and Prx6-Type 1‑Cys Peroxiredoxin Mechanisms

So-called 1-Cys peroxiredoxins (Prx) employ only one cysteine residue for the reduction of hydroperoxides and require an external thiol for the reduction of a reactive sulfenic acid during the catalytic cycle. Hence, 1-Cys Prx, which often belong to the structural Prx5- or the Prx6-type subfamily, a...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS catalysis 2023-03, Vol.13 (6), p.3627-3643
Hauptverfasser:	Lang, Lukas, Wolf, Ann-Cathrin, Riedel, Mareike, Thibol, Lea, Geissel, Fabian, Feld, Kristina, Zimmermann, Jannik, Morgan, Bruce, Manolikakes, Georg, Deponte, Marcel
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!