Flexibility Regulation of Loops Surrounding the Tunnel Entrance in Cytochrome P450 Enhanced Substrate Access Substantially

In recent years, the engineering of flexible loops to improve enzyme properties has gained attention in biocatalysis. Herein, we report a loop engineering strategy to improve the stability of the substrate access tunnels, which reveals the molecular mechanism between loops and tunnels. Based on the...

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Veröffentlicht in:	ACS catalysis 2022-10, Vol.12 (20), p.12800-12808
Hauptverfasser:	Li, Zhongyu, Meng, Shuaiqi, Nie, Kaili, Schwaneberg, Ulrich, Davari, Mehdi D., Xu, Haijun, Ji, Yu, Liu, Luo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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