Automated Nanomole-Scale Reaction Screening toward Benzoate Bioisosteres: A Photocatalyzed Approach to Highly Elaborated Bicyclo[1.1.1]Pentanes

Through the application of high-throughput nanoscale optimization, a mild, photocatalyzed, Minisci-like protocol was developed to access highly functionalized 1,3-disubstituted bicyclopentanes. The benzoate-isosteric compounds were prepared using a readily available organic photocatalyst, mitigating...

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Veröffentlicht in:	ACS catalysis 2022-01, Vol.12 (1), p.600-606
Hauptverfasser:	Mousseau, James J, Perry, Matthew A, Bundesmann, Mark W, Chinigo, Gary M, Choi, Chulho, Gallego, Gary, Hicklin, Robert W, Hoy, Susan, Limburg, David C, Sach, Neal W, Zhang, Yuan
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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