Intrinsic Nucleophilicity of Inverting and Retaining Glycoside Hydrolases Revealed Using Carbasugar Glyco-Tools

Hydrolyses of cyclohexenyl-based carbasugars that mimic either α-d-glucose or α-d-galactose were explored with two Bacteroides thetaiotaomicron enzymes from glycoside hydrolase family 97: an inverting α-glucosidase (BtGH97a) and a retaining α-galactosidase (BtGH97b). Both enzymes yield nucleophilic...

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Veröffentlicht in:	ACS catalysis 2021-08, Vol.11 (15), p.9377-9389
Hauptverfasser:	Akintola, Oluwafemi, Ren, Weiwu, Adabala, Pal John Pal, Bhosale, Sandeep, Wang, Yang, Ganga-Sah, Yumeela, Britton, Robert, Bennet, Andrew J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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