Catalytic Mechanism of Human Ten-Eleven Translocation‑2 (TET2) Enzyme: Effects of Conformational Changes, Electric Field, and Mutations

Ten-eleven translocation (TET) family of enzymes are non-heme Fe­(II)- and 2-oxoglutarate (2OG)-dependent oxygenases that perform oxidation of the methyl group of the 5-methylcytosine (5mC) on DNA. TET enzymes play a crucial role in epigenetic modifications and have been linked to malignant transfor...

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Veröffentlicht in:	ACS catalysis 2021-04, Vol.11 (7), p.3877-3890
Hauptverfasser:	Waheed, Sodiq O, Chaturvedi, Shobhit S, Karabencheva-Christova, Tatyana G, Christov, Christo Z
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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