Cografting of Zwitterionic Sulfobetaines and Cationic Amines on β‑Cyclodextrin-Threaded Polyrotaxanes Facilitates Cellular Association and Tissue Accumulation with High Biocompatibility

β-Cyclodextrins (β-CDs) and β-CD-containing polymers have attracted considerable attention as potential candidates for the treatment of cholesterol-related metabolic and intractable diseases. We have advocated the use of β-CD-threaded acid-degradable polyrotaxanes (PRXs) as intracellular delivery ca...

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Veröffentlicht in:ACS biomaterials science & engineering 2022-06, Vol.8 (6), p.2463-2476
Hauptverfasser: Tamura, Atsushi, Nishida, Kei, Zhang, Shunyao, Kang, Tae Woong, Tonegawa, Asato, Yui, Nobuhiko
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Sprache:eng
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