Efficient Inactivation of Enveloped Viruses Using a Nanoparticle-Based Photodynamic Method

Efficient Inactivation of Enveloped Viruses Using a Nanoparticle-Based Photodynamic Method

Enveloped viruses pose a critical health threat to human beings. Photodynamic inactivation shows promise but requires a relatively long time of irradiation or a high power intensity. Meanwhile, the unclear role of reactive oxygen species (ROS) in inactivation hampers the development of effective ant...

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Veröffentlicht in:ACS applied nano materials 2023-10, Vol.6 (19), p.17647-17656
Hauptverfasser: Zhang, Gengxin, Kuang, Linlin, Liu, Yan, Jiang, Congwei, Yang, Ruihao, Lv, Quanjie, Sun, Kang, Liang, Xiaozhen, Tao, Ke
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container_end_page 17656
container_issue 19
container_start_page 17647
container_title ACS applied nano materials
container_volume 6
creator Zhang, Gengxin
Kuang, Linlin
Liu, Yan
Jiang, Congwei
Yang, Ruihao
Lv, Quanjie
Sun, Kang
Liang, Xiaozhen
Tao, Ke
description Enveloped viruses pose a critical health threat to human beings. Photodynamic inactivation shows promise but requires a relatively long time of irradiation or a high power intensity. Meanwhile, the unclear role of reactive oxygen species (ROS) in inactivation hampers the development of effective antivirus equipment. Here, we present that protoporphyrin IX-loaded silica nanoparticles show high efficiency in inactivating enveloped viruses. Representative enveloped viruses, including herpes simplex virus 1, vesicular stomatitis virus, and pseudoviruses SARS-CoV-2, were almost fully inactivated under
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Photodynamic inactivation shows promise but requires a relatively long time of irradiation or a high power intensity. Meanwhile, the unclear role of reactive oxygen species (ROS) in inactivation hampers the development of effective antivirus equipment. Here, we present that protoporphyrin IX-loaded silica nanoparticles show high efficiency in inactivating enveloped viruses. Representative enveloped viruses, including herpes simplex virus 1, vesicular stomatitis virus, and pseudoviruses SARS-CoV-2, were almost fully inactivated under &lt;16 min of irradiation of a halogen tungsten lamp. By a quantitative polymerase chain reaction technique, we found that the viruses lost their ability to bind cells after the photoinactivation. The mechanistic study further showed that the nanoparticle-based photodynamic effect disrupted the receptor-binding proteins on the envelope rather than destroying the whole virus structure by ROS. 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