Biomimetically Engineered Amyloid-Shelled Gold Nanocomplexes for Discovering α‑Synuclein Oligomer-Degrading Drugs

The assembly of α-synuclein (αS) oligomers is recognized as the main pathological driver of synucleinopathies. While the elimination of toxic αS oligomers shows promise for the treatment of Parkinson’s disease (PD), the discovery of αS oligomer degradation drugs has been hindered by the lack of prop...

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Veröffentlicht in:	ACS applied materials & interfaces 2023-01, Vol.15 (2), p.2538-2551
Hauptverfasser:	Lee, Dongtak, Jung, Hyo Gi, Park, Dongsung, Bang, Junho, Hong, Ji Hye, Lee, Sang Won, Roh, Seokbeom, Jang, Jae Won, Kim, Yonghwan, Hwang, Kyo Seon, Lee, Young-Sun, Park, Jae-Yong, Jung, In Duk, Lee, Jeong Hoon, Lee, Gyudo, Yoon, Dae Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Amyloid - metabolism Amyloidogenic Proteins Biological and Medical Applications of Materials and Interfaces Humans Parkinson Disease - metabolism
Online-Zugang:	Volltext
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