Programmed Multidrug Delivery Based on Bio-Inspired Capsule-Integrated Nanocoatings for Infected Bone Defect Treatment

Infection and delayed wound healing are two major serious complications related to traumatic injuries and cause a significant burden to patients and society. Most currently available drug delivery materials typically carry a single drug, lack protection from drug loading, and face challenges in on-d...

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Veröffentlicht in:	ACS applied materials & interfaces 2021-03, Vol.13 (10), p.12454-12462
Hauptverfasser:	Zhang, Shichao, Vaida, Justin, Parenti, Josh, Lindsey, Brock A, Xing, Malcolm, Li, Bingyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Applications of Polymer, Composite, and Coating Materials Bacterial Infections - drug therapy Biomimetic Materials - chemistry Bone and Bones - injuries Bone and Bones - microbiology Bone Morphogenetic Protein 2 - administration & dosage Bone Morphogenetic Protein 2 - therapeutic use Cell Line Cirsium - chemistry Delayed-Action Preparations - chemistry Humans Interleukin-12 - administration & dosage Interleukin-12 - therapeutic use Nanocapsules - chemistry Peptides - chemistry Rats
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