Programmed Multidrug Delivery Based on Bio-Inspired Capsule-Integrated Nanocoatings for Infected Bone Defect Treatment
Infection and delayed wound healing are two major serious complications related to traumatic injuries and cause a significant burden to patients and society. Most currently available drug delivery materials typically carry a single drug, lack protection from drug loading, and face challenges in on-d...
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| Veröffentlicht in: | ACS applied materials & interfaces 2021-03, Vol.13 (10), p.12454-12462 |
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| container_title | ACS applied materials & interfaces |
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| creator | Zhang, Shichao Vaida, Justin Parenti, Josh Lindsey, Brock A Xing, Malcolm Li, Bingyun |
| description | Infection and delayed wound healing are two major serious complications related to traumatic injuries and cause a significant burden to patients and society. Most currently available drug delivery materials typically carry a single drug, lack protection from drug loading, and face challenges in on-demand and precisely controlled drug release. Here, we report a flower (Cirsium arvense)-inspired capsule-integrated multilayer nanofilm (FICIF), synthesized using a layer-by-layer self-assembly, for programmed multiple drug co-delivery for trauma (open fracture as an example) treatments. Our approach allows polypeptide multilayer nanofilms and innovative impregnated capsules to assemble hierarchical reservoirs with specific drug binding sites, shielding protection capability, and ordered packing structures. The resultant FICIF nanocarriers enable sustained and on-demand co-delivery of a unique immune-tuning cytokine (interleukin 12p70) and a growth factor (bone morphogenetic protein 2) in clinical use, resulting in extraordinary anti-infection (3 orders of magnitude improved bacterial killing) and bone regeneration (5 times enhanced bone healing) in treating infected rat femur fractures. The successful synthesis of these biomimetic high-performance delivery nanocoatings is expected to serve as a source of inspiration for the development of biomaterials for various clinical applications. |
| doi_str_mv | 10.1021/acsami.0c20332 |
| format | Article |
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Most currently available drug delivery materials typically carry a single drug, lack protection from drug loading, and face challenges in on-demand and precisely controlled drug release. Here, we report a flower (Cirsium arvense)-inspired capsule-integrated multilayer nanofilm (FICIF), synthesized using a layer-by-layer self-assembly, for programmed multiple drug co-delivery for trauma (open fracture as an example) treatments. Our approach allows polypeptide multilayer nanofilms and innovative impregnated capsules to assemble hierarchical reservoirs with specific drug binding sites, shielding protection capability, and ordered packing structures. The resultant FICIF nanocarriers enable sustained and on-demand co-delivery of a unique immune-tuning cytokine (interleukin 12p70) and a growth factor (bone morphogenetic protein 2) in clinical use, resulting in extraordinary anti-infection (3 orders of magnitude improved bacterial killing) and bone regeneration (5 times enhanced bone healing) in treating infected rat femur fractures. 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Mater. Interfaces</addtitle><description>Infection and delayed wound healing are two major serious complications related to traumatic injuries and cause a significant burden to patients and society. Most currently available drug delivery materials typically carry a single drug, lack protection from drug loading, and face challenges in on-demand and precisely controlled drug release. Here, we report a flower (Cirsium arvense)-inspired capsule-integrated multilayer nanofilm (FICIF), synthesized using a layer-by-layer self-assembly, for programmed multiple drug co-delivery for trauma (open fracture as an example) treatments. Our approach allows polypeptide multilayer nanofilms and innovative impregnated capsules to assemble hierarchical reservoirs with specific drug binding sites, shielding protection capability, and ordered packing structures. The resultant FICIF nanocarriers enable sustained and on-demand co-delivery of a unique immune-tuning cytokine (interleukin 12p70) and a growth factor (bone morphogenetic protein 2) in clinical use, resulting in extraordinary anti-infection (3 orders of magnitude improved bacterial killing) and bone regeneration (5 times enhanced bone healing) in treating infected rat femur fractures. The successful synthesis of these biomimetic high-performance delivery nanocoatings is expected to serve as a source of inspiration for the development of biomaterials for various clinical applications.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Applications of Polymer, Composite, and Coating Materials</subject><subject>Bacterial Infections - drug therapy</subject><subject>Biomimetic Materials - chemistry</subject><subject>Bone and Bones - injuries</subject><subject>Bone and Bones - microbiology</subject><subject>Bone Morphogenetic Protein 2 - administration & dosage</subject><subject>Bone Morphogenetic Protein 2 - therapeutic use</subject><subject>Cell Line</subject><subject>Cirsium - chemistry</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Humans</subject><subject>Interleukin-12 - administration & dosage</subject><subject>Interleukin-12 - therapeutic use</subject><subject>Nanocapsules - chemistry</subject><subject>Peptides - chemistry</subject><subject>Rats</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kElPwzAQhS0EolC4ckQ5I6V4y3akZatUlkM5RxPHrlwldmQnlfrvcZXSG6fZ3nsafQjdETwjmJJHEB5aPcOCYsboGboiBedxThN6fuo5n6Br77cYp4zi5BJNGEtzlmf0Cu2-nd04aFtZRx9D0-vaDZvoWTZ6J90-moMPB2uiubbx0vhOuzAvoPNDI8Oil8Hch9UnGCss9NpsfKSsi5ZGSXG4zK2RIfAwRWsnoW-l6W_QhYLGy9tjnaKf15f14j1efb0tF0-rGFiG-zihecVToVha0AwqxoBWmMiszrNaUJIWqkiUUIBFSjihOCtSAC4Z5TRRKsFsimZjrnDWeydV2TndgtuXBJcHgOUIsDwCDIb70dANVWBykv8RC4KHURCM5dYOzoT__0v7BVkofDo</recordid><startdate>20210317</startdate><enddate>20210317</enddate><creator>Zhang, Shichao</creator><creator>Vaida, Justin</creator><creator>Parenti, Josh</creator><creator>Lindsey, Brock A</creator><creator>Xing, Malcolm</creator><creator>Li, Bingyun</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-3547-0462</orcidid><orcidid>https://orcid.org/0000-0002-5766-5666</orcidid><orcidid>https://orcid.org/0000-0003-2778-1751</orcidid></search><sort><creationdate>20210317</creationdate><title>Programmed Multidrug Delivery Based on Bio-Inspired Capsule-Integrated Nanocoatings for Infected Bone Defect Treatment</title><author>Zhang, Shichao ; Vaida, Justin ; Parenti, Josh ; Lindsey, Brock A ; Xing, Malcolm ; Li, Bingyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a370t-528b46cf36927ab33a2b01e7d87dc2169f95fcfa0c614120796aa4e32425ff503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Applications of Polymer, Composite, and Coating Materials</topic><topic>Bacterial Infections - drug therapy</topic><topic>Biomimetic Materials - chemistry</topic><topic>Bone and Bones - injuries</topic><topic>Bone and Bones - microbiology</topic><topic>Bone Morphogenetic Protein 2 - administration & dosage</topic><topic>Bone Morphogenetic Protein 2 - therapeutic use</topic><topic>Cell Line</topic><topic>Cirsium - chemistry</topic><topic>Delayed-Action Preparations - chemistry</topic><topic>Humans</topic><topic>Interleukin-12 - administration & dosage</topic><topic>Interleukin-12 - therapeutic use</topic><topic>Nanocapsules - chemistry</topic><topic>Peptides - chemistry</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Shichao</creatorcontrib><creatorcontrib>Vaida, Justin</creatorcontrib><creatorcontrib>Parenti, Josh</creatorcontrib><creatorcontrib>Lindsey, Brock A</creatorcontrib><creatorcontrib>Xing, Malcolm</creatorcontrib><creatorcontrib>Li, Bingyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Shichao</au><au>Vaida, Justin</au><au>Parenti, Josh</au><au>Lindsey, Brock A</au><au>Xing, Malcolm</au><au>Li, Bingyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Programmed Multidrug Delivery Based on Bio-Inspired Capsule-Integrated Nanocoatings for Infected Bone Defect Treatment</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2021-03-17</date><risdate>2021</risdate><volume>13</volume><issue>10</issue><spage>12454</spage><epage>12462</epage><pages>12454-12462</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>Infection and delayed wound healing are two major serious complications related to traumatic injuries and cause a significant burden to patients and society. Most currently available drug delivery materials typically carry a single drug, lack protection from drug loading, and face challenges in on-demand and precisely controlled drug release. Here, we report a flower (Cirsium arvense)-inspired capsule-integrated multilayer nanofilm (FICIF), synthesized using a layer-by-layer self-assembly, for programmed multiple drug co-delivery for trauma (open fracture as an example) treatments. Our approach allows polypeptide multilayer nanofilms and innovative impregnated capsules to assemble hierarchical reservoirs with specific drug binding sites, shielding protection capability, and ordered packing structures. The resultant FICIF nanocarriers enable sustained and on-demand co-delivery of a unique immune-tuning cytokine (interleukin 12p70) and a growth factor (bone morphogenetic protein 2) in clinical use, resulting in extraordinary anti-infection (3 orders of magnitude improved bacterial killing) and bone regeneration (5 times enhanced bone healing) in treating infected rat femur fractures. 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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Applications of Polymer, Composite, and Coating Materials Bacterial Infections - drug therapy Biomimetic Materials - chemistry Bone and Bones - injuries Bone and Bones - microbiology Bone Morphogenetic Protein 2 - administration & dosage Bone Morphogenetic Protein 2 - therapeutic use Cell Line Cirsium - chemistry Delayed-Action Preparations - chemistry Humans Interleukin-12 - administration & dosage Interleukin-12 - therapeutic use Nanocapsules - chemistry Peptides - chemistry Rats |
| title | Programmed Multidrug Delivery Based on Bio-Inspired Capsule-Integrated Nanocoatings for Infected Bone Defect Treatment |
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