Tetrahedral Framework Nucleic Acid Inhibits Chondrocyte Apoptosis and Oxidative Stress through Activation of Autophagy

Osteoarthritis (OA) is a degenerative articular cartilage pathogenic process that is accompanied by excessive chondrocyte apoptosis. The occurrence of chondrocyte death and OA is related to decreased autophagy. Tetrahedral framework nucleic acid (TFNA), a potent bioactive DNA nanomaterial, exerts an...

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Veröffentlicht in:	ACS applied materials & interfaces 2020-12, Vol.12 (51), p.56782-56791
Hauptverfasser:	Shi, Sirong, Tian, Taoran, Li, Yanjing, Xiao, Dexuan, Zhang, Tao, Gong, Ping, Lin, Yunfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Autophagy - drug effects Base Sequence Biological and Medical Applications of Materials and Interfaces Chondrocytes - drug effects DNA - chemistry DNA - pharmacology Materials Science Materials Science, Multidisciplinary Nanoscience & Nanotechnology Nanostructures - chemistry Nucleic Acid Conformation Oxidative Stress - drug effects Protective Agents - chemistry Protective Agents - pharmacology Rats, Sprague-Dawley Science & Technology Science & Technology - Other Topics Technology Wnt Signaling Pathway - drug effects
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