Hypoxia-Responsive Lipid–Polymer Nanoparticle-Combined Imaging-Guided Surgery and Multitherapy Strategies for Glioma
Glioma is the most prevalent type of malignant brain tumor and is usually very aggressive. Because of the high invasiveness and aggressive proliferative growth of glioma, it is difficult to resect completely or cure with surgery. Residual glioma cells are a primary cause of postoperative recurrence....
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| Veröffentlicht in: | ACS applied materials & interfaces 2020-11, Vol.12 (47), p.52319-52328 |
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| creator | Xu, Haoyue Han, Yuhan Zhao, Gang Zhang, Long Zhao, Zongren Wang, Zhen Zhao, Liang Hua, Lei Naveena, Konduru Lu, Jun Yu, Rutong Liu, Hongmei |
| description | Glioma is the most prevalent type of malignant brain tumor and is usually very aggressive. Because of the high invasiveness and aggressive proliferative growth of glioma, it is difficult to resect completely or cure with surgery. Residual glioma cells are a primary cause of postoperative recurrence. Herein, we describe a hypoxia-responsive lipid polymer nanoparticle (LN) for fluorescence-guided surgery, chemotherapy, photodynamic therapy (PDT), and photothermal therapy (PTT) combination multitherapy strategies targeting glioma. The hypoxia-responsive LN [LN (DOX + ICG)] contains a hypoxia-responsive component poly(nitroimidazole)25 [P-(Nis)25], the glioma-targeting peptide angiopep-2 (A2), indocyanine green (ICG), and doxorubicin (DOX). LN (DOX + ICG) comprises four distinct functional components: (1) A2: A2 modified nanoparticles effectively target gliomas, enhancing drug concentration in gliomas; (2) P-(Nis)25: (i) the hydrophobic component of LN (DOX + ICG) with hypoxia responsive ability to encapsulate DOX and ICG; (ii) allows rapid release of DOX from LN (DOX + ICG) after 808 nm laser irradiation; (3) ICG: (i) ICG allows imaging-guided surgery, combining PDT and PTT therapies; (ii) upon irradiation with an 808 nm laser, ICG creates a hypoxic environment; (4) DOX inhibits glioma growth. This work demonstrates that LN (DOX + ICG) might provide a novel clinical approach to preventing post-surgical recurrence of glioma. |
| doi_str_mv | 10.1021/acsami.0c12971 |
| format | Article |
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Because of the high invasiveness and aggressive proliferative growth of glioma, it is difficult to resect completely or cure with surgery. Residual glioma cells are a primary cause of postoperative recurrence. Herein, we describe a hypoxia-responsive lipid polymer nanoparticle (LN) for fluorescence-guided surgery, chemotherapy, photodynamic therapy (PDT), and photothermal therapy (PTT) combination multitherapy strategies targeting glioma. The hypoxia-responsive LN [LN (DOX + ICG)] contains a hypoxia-responsive component poly(nitroimidazole)25 [P-(Nis)25], the glioma-targeting peptide angiopep-2 (A2), indocyanine green (ICG), and doxorubicin (DOX). LN (DOX + ICG) comprises four distinct functional components: (1) A2: A2 modified nanoparticles effectively target gliomas, enhancing drug concentration in gliomas; (2) P-(Nis)25: (i) the hydrophobic component of LN (DOX + ICG) with hypoxia responsive ability to encapsulate DOX and ICG; (ii) allows rapid release of DOX from LN (DOX + ICG) after 808 nm laser irradiation; (3) ICG: (i) ICG allows imaging-guided surgery, combining PDT and PTT therapies; (ii) upon irradiation with an 808 nm laser, ICG creates a hypoxic environment; (4) DOX inhibits glioma growth. This work demonstrates that LN (DOX + ICG) might provide a novel clinical approach to preventing post-surgical recurrence of glioma.</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.0c12971</identifier><identifier>PMID: 33166112</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Animals ; Antibiotics, Antineoplastic - chemistry ; Antibiotics, Antineoplastic - pharmacology ; Antibiotics, Antineoplastic - therapeutic use ; Biological and Medical Applications of Materials and Interfaces ; Cell Line, Tumor ; Cell Survival - drug effects ; Doxorubicin - chemistry ; Doxorubicin - pharmacology ; Doxorubicin - therapeutic use ; Female ; Glioma - diagnostic imaging ; Glioma - drug therapy ; Glioma - pathology ; Humans ; Indocyanine Green - chemistry ; Indocyanine Green - pharmacology ; Indocyanine Green - therapeutic use ; Infrared Rays ; Lipids - chemistry ; Mice ; Mice, Inbred ICR ; Nanoparticles - chemistry ; Peptides - chemistry ; Peptides - therapeutic use ; Photochemotherapy ; Photosensitizing Agents - chemistry ; Photosensitizing Agents - pharmacology ; Photosensitizing Agents - therapeutic use ; Photothermal Therapy ; Polymers - chemistry ; Transplantation, Heterologous</subject><ispartof>ACS applied materials & interfaces, 2020-11, Vol.12 (47), p.52319-52328</ispartof><rights>2020 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a330t-a0fc84acedc806a06f213c3e68429a6789b399668ebdace9b67ab23a6a7eb5f3</citedby><cites>FETCH-LOGICAL-a330t-a0fc84acedc806a06f213c3e68429a6789b399668ebdace9b67ab23a6a7eb5f3</cites><orcidid>0000-0001-8533-1973 ; 0000-0002-9175-4291 ; 0000-0002-0473-0030</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.0c12971$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.0c12971$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33166112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Haoyue</creatorcontrib><creatorcontrib>Han, Yuhan</creatorcontrib><creatorcontrib>Zhao, Gang</creatorcontrib><creatorcontrib>Zhang, Long</creatorcontrib><creatorcontrib>Zhao, Zongren</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>Zhao, Liang</creatorcontrib><creatorcontrib>Hua, Lei</creatorcontrib><creatorcontrib>Naveena, Konduru</creatorcontrib><creatorcontrib>Lu, Jun</creatorcontrib><creatorcontrib>Yu, Rutong</creatorcontrib><creatorcontrib>Liu, Hongmei</creatorcontrib><title>Hypoxia-Responsive Lipid–Polymer Nanoparticle-Combined Imaging-Guided Surgery and Multitherapy Strategies for Glioma</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. 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LN (DOX + ICG) comprises four distinct functional components: (1) A2: A2 modified nanoparticles effectively target gliomas, enhancing drug concentration in gliomas; (2) P-(Nis)25: (i) the hydrophobic component of LN (DOX + ICG) with hypoxia responsive ability to encapsulate DOX and ICG; (ii) allows rapid release of DOX from LN (DOX + ICG) after 808 nm laser irradiation; (3) ICG: (i) ICG allows imaging-guided surgery, combining PDT and PTT therapies; (ii) upon irradiation with an 808 nm laser, ICG creates a hypoxic environment; (4) DOX inhibits glioma growth. This work demonstrates that LN (DOX + ICG) might provide a novel clinical approach to preventing post-surgical recurrence of glioma.</description><subject>Animals</subject><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Antibiotics, Antineoplastic - therapeutic use</subject><subject>Biological and Medical Applications of Materials and Interfaces</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - pharmacology</subject><subject>Doxorubicin - therapeutic use</subject><subject>Female</subject><subject>Glioma - diagnostic imaging</subject><subject>Glioma - drug therapy</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Indocyanine Green - chemistry</subject><subject>Indocyanine Green - pharmacology</subject><subject>Indocyanine Green - therapeutic use</subject><subject>Infrared Rays</subject><subject>Lipids - chemistry</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Nanoparticles - chemistry</subject><subject>Peptides - chemistry</subject><subject>Peptides - therapeutic use</subject><subject>Photochemotherapy</subject><subject>Photosensitizing Agents - chemistry</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Photothermal Therapy</subject><subject>Polymers - chemistry</subject><subject>Transplantation, Heterologous</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKw0AUhgdRbK1uXcqshdS5pJNkKUXbQr1guw8nk0mckmTCTFLMznfwDX0SI6nduTrnwPf_HD6ErimZUsLoHUgHpZ4SSVkU0BM0ppHveyGbsdPj7vsjdOHcjhDBGZmdoxHnVAhK2Rjtl11tPjR4b8rVpnJ6r_Ba1zr9_vx6NUVXKoufoTI12EbLQnlzUya6UilelZDrKvcWrU77c9PaXNkOQ5Xip7ZodPOuLNQd3jQWGpVr5XBmLF4U2pRwic4yKJy6OswJ2j4-bOdLb_2yWM3v1x5wThoPSCZDH6RKZUgEEJExyiVXIvRZBCIIo4RHkRChStKeihIRQMI4CAhUMsv4BE2HWmmNc1ZlcW11CbaLKYl__cWDv_jgrw_cDIG6TUqVHvE_YT1wOwB9MN6Z1lb9-_-1_QDYP38N</recordid><startdate>20201125</startdate><enddate>20201125</enddate><creator>Xu, Haoyue</creator><creator>Han, Yuhan</creator><creator>Zhao, Gang</creator><creator>Zhang, Long</creator><creator>Zhao, Zongren</creator><creator>Wang, Zhen</creator><creator>Zhao, Liang</creator><creator>Hua, Lei</creator><creator>Naveena, Konduru</creator><creator>Lu, Jun</creator><creator>Yu, Rutong</creator><creator>Liu, Hongmei</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-8533-1973</orcidid><orcidid>https://orcid.org/0000-0002-9175-4291</orcidid><orcidid>https://orcid.org/0000-0002-0473-0030</orcidid></search><sort><creationdate>20201125</creationdate><title>Hypoxia-Responsive Lipid–Polymer Nanoparticle-Combined Imaging-Guided Surgery and Multitherapy Strategies for Glioma</title><author>Xu, Haoyue ; Han, Yuhan ; Zhao, Gang ; Zhang, Long ; Zhao, Zongren ; Wang, Zhen ; Zhao, Liang ; Hua, Lei ; Naveena, Konduru ; Lu, Jun ; Yu, Rutong ; Liu, Hongmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a330t-a0fc84acedc806a06f213c3e68429a6789b399668ebdace9b67ab23a6a7eb5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Antibiotics, Antineoplastic - therapeutic use</topic><topic>Biological and Medical Applications of Materials and Interfaces</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - pharmacology</topic><topic>Doxorubicin - therapeutic use</topic><topic>Female</topic><topic>Glioma - diagnostic imaging</topic><topic>Glioma - drug therapy</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Indocyanine Green - chemistry</topic><topic>Indocyanine Green - pharmacology</topic><topic>Indocyanine Green - therapeutic use</topic><topic>Infrared Rays</topic><topic>Lipids - chemistry</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Nanoparticles - chemistry</topic><topic>Peptides - chemistry</topic><topic>Peptides - therapeutic use</topic><topic>Photochemotherapy</topic><topic>Photosensitizing Agents - chemistry</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Photothermal Therapy</topic><topic>Polymers - chemistry</topic><topic>Transplantation, Heterologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Haoyue</creatorcontrib><creatorcontrib>Han, Yuhan</creatorcontrib><creatorcontrib>Zhao, Gang</creatorcontrib><creatorcontrib>Zhang, Long</creatorcontrib><creatorcontrib>Zhao, Zongren</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>Zhao, Liang</creatorcontrib><creatorcontrib>Hua, Lei</creatorcontrib><creatorcontrib>Naveena, Konduru</creatorcontrib><creatorcontrib>Lu, Jun</creatorcontrib><creatorcontrib>Yu, Rutong</creatorcontrib><creatorcontrib>Liu, Hongmei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Haoyue</au><au>Han, Yuhan</au><au>Zhao, Gang</au><au>Zhang, Long</au><au>Zhao, Zongren</au><au>Wang, Zhen</au><au>Zhao, Liang</au><au>Hua, Lei</au><au>Naveena, Konduru</au><au>Lu, Jun</au><au>Yu, Rutong</au><au>Liu, Hongmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoxia-Responsive Lipid–Polymer Nanoparticle-Combined Imaging-Guided Surgery and Multitherapy Strategies for Glioma</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2020-11-25</date><risdate>2020</risdate><volume>12</volume><issue>47</issue><spage>52319</spage><epage>52328</epage><pages>52319-52328</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>Glioma is the most prevalent type of malignant brain tumor and is usually very aggressive. Because of the high invasiveness and aggressive proliferative growth of glioma, it is difficult to resect completely or cure with surgery. Residual glioma cells are a primary cause of postoperative recurrence. Herein, we describe a hypoxia-responsive lipid polymer nanoparticle (LN) for fluorescence-guided surgery, chemotherapy, photodynamic therapy (PDT), and photothermal therapy (PTT) combination multitherapy strategies targeting glioma. The hypoxia-responsive LN [LN (DOX + ICG)] contains a hypoxia-responsive component poly(nitroimidazole)25 [P-(Nis)25], the glioma-targeting peptide angiopep-2 (A2), indocyanine green (ICG), and doxorubicin (DOX). LN (DOX + ICG) comprises four distinct functional components: (1) A2: A2 modified nanoparticles effectively target gliomas, enhancing drug concentration in gliomas; (2) P-(Nis)25: (i) the hydrophobic component of LN (DOX + ICG) with hypoxia responsive ability to encapsulate DOX and ICG; (ii) allows rapid release of DOX from LN (DOX + ICG) after 808 nm laser irradiation; (3) ICG: (i) ICG allows imaging-guided surgery, combining PDT and PTT therapies; (ii) upon irradiation with an 808 nm laser, ICG creates a hypoxic environment; (4) DOX inhibits glioma growth. This work demonstrates that LN (DOX + ICG) might provide a novel clinical approach to preventing post-surgical recurrence of glioma.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>33166112</pmid><doi>10.1021/acsami.0c12971</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8533-1973</orcidid><orcidid>https://orcid.org/0000-0002-9175-4291</orcidid><orcidid>https://orcid.org/0000-0002-0473-0030</orcidid></addata></record> |
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| ispartof | ACS applied materials & interfaces, 2020-11, Vol.12 (47), p.52319-52328 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Antibiotics, Antineoplastic - therapeutic use Biological and Medical Applications of Materials and Interfaces Cell Line, Tumor Cell Survival - drug effects Doxorubicin - chemistry Doxorubicin - pharmacology Doxorubicin - therapeutic use Female Glioma - diagnostic imaging Glioma - drug therapy Glioma - pathology Humans Indocyanine Green - chemistry Indocyanine Green - pharmacology Indocyanine Green - therapeutic use Infrared Rays Lipids - chemistry Mice Mice, Inbred ICR Nanoparticles - chemistry Peptides - chemistry Peptides - therapeutic use Photochemotherapy Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Photothermal Therapy Polymers - chemistry Transplantation, Heterologous |
| title | Hypoxia-Responsive Lipid–Polymer Nanoparticle-Combined Imaging-Guided Surgery and Multitherapy Strategies for Glioma |
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