Nanoparticle Delivery of MnO 2 and Antiangiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma

Antiangiogenic therapy is widely administered in many cancers, and the antiangiogenic drug sorafenib offers moderate benefits in advanced hepatocellular carcinoma (HCC). However, antiangiogenic therapy can also lead to hypoxia-driven angiogenesis and immunosuppression in the tumor microenvironment (...

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Veröffentlicht in:	ACS applied materials & interfaces 2020-10, Vol.12 (40), p.44407-44419
Hauptverfasser:	Chang, Chih-Chun, Dinh, Trinh Kieu, Lee, Yi-An, Wang, Fu-Nien, Sung, Yun-Chieh, Yu, Pei-Lun, Chiu, Shao-Chieh, Shih, Yu-Chuan, Wu, Cheng-Yun, Huang, Yi-Da, Wang, Jane, Lu, Tsai-Te, Wan, Dehui, Chen, Yunching
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Drug Carriers - chemistry Drug Carriers - pharmacology Humans Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male Manganese Compounds - chemistry Manganese Compounds - pharmacology Mice Mice, Inbred C3H Nanoparticles - chemistry Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Oxides - chemistry Oxides - pharmacology Particle Size Surface Properties Tumor Cells, Cultured Tumor Escape - drug effects Tumor Hypoxia - drug effects
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