Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome

Two process routes for LX1031, a tryptophan hydroxylase inhibitor for the treatment of irritable bowel syndrome, were developed. They shared the same left-hand and right-hand starting materials as well as the penultimate intermediate. The chiral center in the left-hand moiety was established via a N...

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Veröffentlicht in:	Organic process research & development 2020-02, Vol.24 (2), p.261-273
Hauptverfasser:	Zhao, Matthew M, Zhang, Haiming, Iimura, Shinya, Bednarz, Mark S, Kanamarlapudi, Ramanaiah C, Yan, Jie, Lim, Ngiap-Kie, Wu, Wenxue
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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