Improved Tag-Assisted Liquid-Phase Peptide Synthesis: Application to the Synthesis of the Bradykinin Receptor Antagonist Icatibant Acetate

A cost- and time-effective synthetic method is a prerequisite to producing therapeutic peptides on a commercial scale. Herein we demonstrate that a soluble-tag-assisted liquid-phase peptide synthesis (LPPS) using a hydrophobic benzyl alcohol as a support is applicable to the 100 g scale production o...

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Veröffentlicht in:	Organic process research & development 2019-11, Vol.23 (11), p.2576-2581
Hauptverfasser:	Okada, Yohei, Takasawa, Rico, Kubo, Daisuke, Iwanaga, Natsumi, Fujita, Shuji, Suzuki, Kosuke, Suzuki, Hideaki, Kamiya, Hidehiro, Chiba, Kazuhiro
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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