Collaborative Evaluation of Commercially Available Automated Powder Dispensing Platforms for High-Throughput Experimentation in Pharmaceutical Applications

Collaborative Evaluation of Commercially Available Automated Powder Dispensing Platforms for High-Throughput Experimentation in Pharmaceutical Applications

Many workflows in Pharmaceutical R&D involve the manipulation of defined amounts of powders. Automated powder dispensing platforms are currently available; however, these existing technologies do not meet the requirements for every high-throughput experimentation powder dispensing application. A...

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Veröffentlicht in:Organic process research & development 2018-11, Vol.22 (11), p.1500-1508
Hauptverfasser: Bahr, Matthew N, Damon, David B, Yates, Simon D, Chin, Alexander S, Christopher, J. David, Cromer, Samuel, Perrotto, Nicholas, Quiroz, Jorge, Rosso, Victor
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container_end_page 1508
container_issue 11
container_start_page 1500
container_title Organic process research & development
container_volume 22
creator Bahr, Matthew N
Damon, David B
Yates, Simon D
Chin, Alexander S
Christopher, J. David
Cromer, Samuel
Perrotto, Nicholas
Quiroz, Jorge
Rosso, Victor
description Many workflows in Pharmaceutical R&D involve the manipulation of defined amounts of powders. Automated powder dispensing platforms are currently available; however, these existing technologies do not meet the requirements for every high-throughput experimentation powder dispensing application. A Working Group (WG) composed of pharmaceutical researchers within the Enabling Technologies Consortium (ETC) evaluated automated platforms commercially available from three manufacturers using an objective, systematic testing protocol. This paper describes the selection of powders and testing conditions used in this evaluation, and it assesses the impact that the powders, testing conditions, equipment environment, and other factors had on the performance of the selected platforms.
doi_str_mv 10.1021/acs.oprd.8b00259
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title Collaborative Evaluation of Commercially Available Automated Powder Dispensing Platforms for High-Throughput Experimentation in Pharmaceutical Applications
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