The First Asymmetric Pilot-Scale Synthesis of TV-45070

TV-45070 is a small-molecule lactam containing a chiral spiro-ether that has been reported as a potential topical therapy for pain associated with the Nav1.7 sodium ion channel encoded by the gene SCN9A. A pilot-scale synthesis is presented that is highlighted by an asymmetric aldol coupling at ambi...

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Veröffentlicht in:	Organic process research & development 2017-10, Vol.21 (10), p.1616-1624
Hauptverfasser:	Sclafani, Joseph A, Chen, Jian, Levy, Daniel V, Reese, Harlan, Dimitri, Mina, Mudipalli, Partha, Christie, Michael, Neville, Christopher J, Olsen, Mark, Bakale, Roger P
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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