Development of Large-Scale Routes to Potent GPR119 Receptor Agonists
Practical and scalable syntheses were developed that were used to prepare multikilogram batches of GSK1292263A (1) and GSK2041706A (15), two potent G protein-coupled receptor 119 (GPR119) agonists. Both syntheses employed relatively cheap and readily available starting materials, and both took advan...
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| Veröffentlicht in: | Organic process research & development 2016-08, Vol.20 (8), p.1469-1475 |
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| container_title | Organic process research & development |
| container_volume | 20 |
| creator | Matsuoka, Richard T Boros, Eric E Brown, Andrew D Bullock, Kae M Canoy, Will L Carpenter, Andrew J Cobb, Jeremy D Condon, Shannon E Deschamps, Nicole M Elitzin, Vassil I Erickson, Greg Fang, Jing M Igo, David H Joshi, Biren K Kaldor, Istvan W Mitchell, Mark B Peckham, Gregory E Reynolds, Daniel W Salmon, Matthew C Sharp, Matthew J Tabet, Elie A Toczko, Jennifer F Wu, Lianming Michael Zhou, Xiao-ming M |
| description | Practical and scalable syntheses were developed that were used to prepare multikilogram batches of GSK1292263A (1) and GSK2041706A (15), two potent G protein-coupled receptor 119 (GPR119) agonists. Both syntheses employed relatively cheap and readily available starting materials, and both took advantage of an SNAr synthetic strategy. |
| doi_str_mv | 10.1021/acs.oprd.6b00157 |
| format | Article |
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| source | ACS Publications |
| title | Development of Large-Scale Routes to Potent GPR119 Receptor Agonists |
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