Development of a Practical Process for the Synthesis of PDE4 Inhibitors

A practical, safe, and efficient process for the synthesis of PDE4 (phosphodiesterase type 4) inhibitors represented by 1 and 2 was developed and demonstrated on a multi-kilogram scale. Key aspects of the process include the regioselective synthesis of dihydrothieno­[3,2-d]­pyrimidine-2,4-diol 9 and...

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Veröffentlicht in:	Organic process research & development 2016-05, Vol.20 (5), p.982-988
Hauptverfasser:	Frutos, Rogelio P, Tampone, Thomas G, Mulder, Jason A, Rodriguez, Sonia, Yee, Nathan K, Yang, Bing-Shiou, Senanayake, Chris H
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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