The Development of a Manufacturing Route to an MCHr1 Antagonist

The Development of a Manufacturing Route to an MCHr1 Antagonist

Process development work to provide an efficient manufacturing route to a MCHr1 antagonist is presented herewith. Features of this development work include a scalable manufacturing route to the useful 6-oxa-2-azaspiro[3.3]­heptane building block and the use of a (soluble) alternative to sodium triac...

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Veröffentlicht in:Organic process research & development 2016-03, Vol.20 (3), p.675-682
Hauptverfasser: Golden, Michael, Legg, Danny, Milne, David, Bharadwaj M, Arun, Deepthi, K, Gopal, Madan, Dokka, Nagaraju, Nambiar, Sudhir, Ramachandra, Puranik, Santhosh, U, Sharma, Parhalad, Sridharan, R, Sulur, Manjunatha, Linderberg, Mats, Nilsson, Anders, Sohlberg, Roger, Kremers, John, Oliver, Samuel, Patra, Debasis
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Sprache:eng
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Zusammenfassung:Process development work to provide an efficient manufacturing route to a MCHr1 antagonist is presented herewith. Features of this development work include a scalable manufacturing route to the useful 6-oxa-2-azaspiro[3.3]­heptane building block and the use of a (soluble) alternative to sodium triacetoxyborohydride.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.6b00006