Application of On-Line NIR for Process Control during the Manufacture of Sitagliptin

The transamination-chemistry-based process for sitagliptin is a through-process, which challenges the crystallization of the active pharmaceutical ingredient (API) in a batch stream composed of multiple components. Risk-assessment-based design of experiment (DoE) studies of particle size distributio...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Organic process research & development 2016-03, Vol.20 (3), p.653-660
Hauptverfasser:	Zhou, George, Grosser, Shane, Sun, Lei, Graffius, Gabriel, Prasad, Ganeshwar, Moment, Aaron, Spartalis, Angela, Fernandez, Paul, Higgins, John, Wabuyele, Busolo, Starbuck, Cindy
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!