Continuous Liquid Vapor Reactions Part 2: Asymmetric Hydroformylation with Rhodium-Bisdiazaphos Catalysts in a Vertical Pipes-in-Series Reactor
Asymmetric hydroformylation (AHF) of 2-vinyl-6-methoxynaphthalene demonstrates important design characteristics of a vertical pipes-in-series plug flow reactor (PFR). The regio- and enantioselectivity of the AHF reaction provide a chemical probe of gas–liquid mixing in a flow reactor for comparison...
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| Veröffentlicht in: | Organic process research & development 2016-05, Vol.20 (5), p.901-910 |
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| container_title | Organic process research & development |
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| creator | Abrams, M. Leigh Buser, Jonas Y Calvin, Joel R Johnson, Martin D Jones, Bradley R Lambertus, Gordon Landis, Clark R Martinelli, Joseph R May, Scott A McFarland, Adam D Stout, James R |
| description | Asymmetric hydroformylation (AHF) of 2-vinyl-6-methoxynaphthalene demonstrates important design characteristics of a vertical pipes-in-series plug flow reactor (PFR). The regio- and enantioselectivity of the AHF reaction provide a chemical probe of gas–liquid mixing in a flow reactor for comparison with well-stirred batch reactors. Results obtained with the flow reactor compare favorably to those obtained in batch. Thus, AHF provides an efficient, in-flow enantioselective synthesis of (S)-Naproxen. |
| doi_str_mv | 10.1021/acs.oprd.5b00406 |
| format | Article |
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| source | ACS Publications |
| title | Continuous Liquid Vapor Reactions Part 2: Asymmetric Hydroformylation with Rhodium-Bisdiazaphos Catalysts in a Vertical Pipes-in-Series Reactor |
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