Development of an Efficient Synthesis of (2-Aminopyrimidin-5-yl) Boronic Acid

A practical and cost-effective synthesis of (2-aminopyrimidin-5-yl) boronic acid 1b has been developed. Key features of the synthesis include the inexpensive in situ protection of the amine via bis-silylation using TMSCl followed by metal–halogen exchange using n-BuLi and trapping with B­(Oi-Pr)3. T...

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Veröffentlicht in:	Organic process research & development 2016-01, Vol.20 (1), p.95-99
Hauptverfasser:	Patel, Nitinchandra D, Zhang, Yongda, Gao, Joe, Sidhu, Kanwar, Lorenz, Jon C, Fandrick, Keith R, Mulder, Jason A, Herbage, Melissa A, Li, Zhibin, Ma, Shengli, Lee, Heewon, Grinberg, Nelu, Song, Jinhua J, Busacca, Carl A, Yee, Nathan K, Senanayake, Chris H
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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