Kinetics Model for Designing Grignard Reactions in Batch or Flow Operations

This paper describes the development of a “fit for use” model for a Grignard reaction, which was used to produce an intermediate compound during the manufacture of API for edivoxetine hydrochloride. The model includes three parameters, one (k SL a) of them representing the mass-transfer component an...

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Veröffentlicht in:	Organic process research & development 2016-02, Vol.20 (2), p.525-539
Hauptverfasser:	Changi, Shujauddin M, Wong, Sze-Wing
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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