Development of a Mechanism-Based Kinetic Model and Process Optimization Incorporating Imidazole Autocatalysis in a 1,1′-Thiocarbonyldiimidazole-Mediated Thiocarbonyl Transfer

The synthesis of mixed thiourea 4 was performed via a 1,1′-thiocarbonyldiimidazole (TCDI)-mediated coupling with 1 to form intermediate isothiocyanate 2 prior to reaction with amine 3. A critical undesired thiourea impurity5is formed via the overreaction of 2 with an additional equivalent of 1. Th...

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Veröffentlicht in:	Organic process research & development 2024-07, Vol.28 (7), p.2481-2487
1. Verfasser:	Paul-Gorsline, Bradley J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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