Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1Process History and Development Strategy

An improved synthesis has been developed for belzutifan, a novel HIF-2α inhibitor for the treatment of Von Hippel–Lindau (VHL) disease-associated renal cell carcinoma (RCC). The efficiency of previous supply and commercial routes was encumbered by a lengthy 5-step sequence, needed to install a chira...

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Veröffentlicht in:	Organic process research & development 2024-02, Vol.28 (2), p.404-412
Hauptverfasser:	DiRocco, Daniel A., Zhong, Yong-Li, Le, Diane N., McCann, Scott D., Hethcox, J. Caleb, Kim, Jungchul, Kolev, Joshua N., Kosjek, Birgit, Dalby, Stephen M., McMullen, Jonathan P., Gangam, Rekha, Morris, William J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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