Gram-Scale Synthesis of the C14–C23 Fragment of Eribulin

Gram-Scale Synthesis of the C14–C23 Fragment of Eribulin

Eribulin is a structurally simplified and completely synthetic analogue of macrocyclic ketone halichondrin B. In 2010, eribulin was approved by FDA for the treatment of metastatic breast cancer (MBC). Although several research groups have reported the synthetic efforts toward eribulin, it is still a...

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Veröffentlicht in:Organic process research & development 2023-02, Vol.27 (2), p.367-372
Hauptverfasser: Yu, Qiuhan, Zhou, Yueer, Gao, Xinai, Pan, Shuheng, Lin, Feng, Li, Wei
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container_issue 2
container_start_page 367
container_title Organic process research & development
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creator Yu, Qiuhan
Zhou, Yueer
Gao, Xinai
Pan, Shuheng
Lin, Feng
Li, Wei
description Eribulin is a structurally simplified and completely synthetic analogue of macrocyclic ketone halichondrin B. In 2010, eribulin was approved by FDA for the treatment of metastatic breast cancer (MBC). Although several research groups have reported the synthetic efforts toward eribulin, it is still a challenge to prepare eribulin in a large scale due to its complex molecular architecture. Herein, we report a novel and efficient route to the C14–C23 fragment of eribulin from cheap l-arabinose.
doi_str_mv 10.1021/acs.oprd.2c00370
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title Gram-Scale Synthesis of the C14–C23 Fragment of Eribulin
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